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Dose-Response Relationship of a Uricosuric Diuretic

  • B. T. Emmerson
  • L. Thompson
  • K. Mitchell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics. Initial studies had confirmed that a 10 mg dose was diuretic in healthy volunteers but had very little effect upon the serum urate concentration. An important question therefore was to decide whether larger doses of the drug would have a greater uricosuric effect without a corresponding increase in the natriuretic or kaluretic effects.

Keywords

Urine Flow Rate Serum Urate Concentration Princess Alexandra Hospital Allocation Schedule Uricosuric Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    FANELLI, G.M., BOHN, D.L., HORBATY, C.A., BEYER, K.H. and SCRIABINE, A. Kidney International 6:40A (1974).Google Scholar
  2. 2.
    STEELE, T.H. and OPPENHEIMER, S. Am. J. Med. 47:564–574 (1969).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. T. Emmerson
    • 1
  • L. Thompson
    • 1
  • K. Mitchell
    • 1
  1. 1.Princess Alexandra HospitalUniversity of Queensland Department of MedicineBrisbaneAustralia

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