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The Influence of Allopurinol in Customary and in Slow Release Preparation on Different Parameters of Purine and Pyrimidine Metabolism

  • W. Gröbner
  • I. Walter
  • A. Rauch-Janssen
  • N. Zöllner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

Allopurinol is widely used as a hypouricemic agent in man. This compound serves as both a substrate and an inhibitor of xanthine oxidase the enzyme which catalyses the oxidation of hypoxanthine to xanthine and xanthine to uric acid. Allopurinol itself is rapidly oxidized in vivo by xanthine oxidase to oxipurinol, which is also an inhibitor of xanthine oxidase,

Keywords

Uric Acid Xanthine Oxidase Serum Uric Acid Renal Excretion Uric Acid Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fox, R. M.; Royse-Smith, D.; O’Sullivan, W. J.: Science 168, 861 (1970)PubMedCrossRefGoogle Scholar
  2. Kelley, W. N.; Beardmore, T. D.: Science l69, 388 (1970)CrossRefGoogle Scholar
  3. Rogers, L. E.; Porter, P. St.: Pediatrics 42, 423 (1968)PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • W. Gröbner
    • 1
  • I. Walter
    • 1
  • A. Rauch-Janssen
    • 1
  • N. Zöllner
    • 1
  1. 1.Medical PolyclinicUniversity of MunichMunichGermany

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