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The Effect of Different Purines and Pyrimidines on Human Pyrimidine Biosynthesis

  • N. Zöllner
  • W. Gröbner
  • A. Rauch-Janssen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

Hereditary orotaciduria is caused by the patient’s inability to convert orotic acid to uridine monophosphate, due to an absence of the activity of orotidine phosphate decarboxylase in all cases and orotate phosphoribosyl-transferase in all cases but one. All or nearly all of the orotic acid formed by biosynthesis must be excreted or degraded. Therefore, urinary excretion permits an estimation of pyrimidine biosynthesis. Children with the disease excrete 1.0 to 1.5 grammes of orotic acid per day while the normal excretion of orotic acid is only 1.4 mg/d.

Keywords

Guanosine Monophosphate Orotic Acid Pyrimidine Biosynthesis Carbamyl Phosphate Formula Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • N. Zöllner
    • 1
  • W. Gröbner
    • 1
  • A. Rauch-Janssen
    • 1
  1. 1.Medizinische PoliklinikUniversität MünchenMünchen 2Germany

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