Renal Tubular Transport of Urate in Fanconi Syndrome
Recent studies of renal urate handling in man have provided evidence for a model of urate transport which includes the following sequence: 1) uric acid is filtered at the glomerulus; 2) filtered urate is extensively, if not completely, reabsorbed in the proximal tubule; 3) additional urate enters the tubule by secretion; and 4) there is substantial reabsorption of secreted urate coextensive with and/or distal to the urate secretory site (1) (Figure 1). In accordance with this model, hyperuricosuria might result from enhanced secretion or diminished reabsorption of either filtered or secreted urate.
KeywordsUric Acid Sickle Cell Anemia Serum Uric Acid Acidosis Renal Tubular Fanconi Syndrome
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