Typing of Uric Acid Level in Cerebrospinal Fluid in Neurological and Psychiatric Diseases

  • Frieder Láhoda
  • Dieter Athen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)


The increasing number of uric acid metabolism disorders that either are clinically latent or become manifest, plays an important role in the differential diagnosis of neurological and psychiatric disorders. Besides the still largely unsolved problems concerning the clinical significance of uric acid metabolism disorders in this kind of diseases the question arises whether uric acid possibly has a regulative function within the central nervous system under physiological conditions. The basis for this hypothesis is the fact, that famous people suffering from gouty arthitis often were unusually bright minds up to a high age. For example remember Rubens, Leibniz and Frederic 2 of Prussia. RIGDWAY showed in comparative studies in delphines, which are animals with a more than average “intelligence”, that they have a high serum uric acid level. In 1955 ORWAN made the hypothesis that the uricase deficiency and the resulting excess of uric acid might have been one of the main reasons for the dominating development of the intellectual power of the hominides in the course of the evolution. He suspected that uric acid like caffein stimulates the cerebral cortex.


Uric Acid Serum Uric Acid Bacterial Meningitis Uric Acid Level Serum Uric Acid Level 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Frieder Láhoda
    • 1
  • Dieter Athen
    • 1
  1. 1.Neurological and Psychiatric Clinic Univ.MunichGermany

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