Alterations of Human Purine Metabolism in Megaloblastic Anemia

  • Irving H. Fox
  • Dale A. Dotten
  • Pamela J. Marchant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)


Secondary hyperuricemias in hematological diseases are frequently related to an increased turnover of nucleic acid purine in rapidly proliferating cells or in hyperplastic tissue (1). Transient hyperuricemia, hyperuricosuria and acute gouty arthritis have occurred during liver extract induced reticulocytosis and during the therapy for deficiencies of folic acid or iron (1–4). To further explore the acute alterations of purine metabolism, we have investigated 7 patients with severe megaloblastic anemia for changes of uric acid metabolism and 3 important erythrocyte enzymes of purine metabolism (5).


Uric Acid Serum Uric Acid Purine Metabolism Megaloblastic Anemia Plasma Uric Acid 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Irving H. Fox
    • 1
  • Dale A. Dotten
    • 1
  • Pamela J. Marchant
    • 1
  1. 1.Purine Research Laboratory, Rheumatic Disease Unit, Wellesley HospitalUniversity of TorontoTorontoCanada

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