Alterations of Human Purine Metabolism in Megaloblastic Anemia
Secondary hyperuricemias in hematological diseases are frequently related to an increased turnover of nucleic acid purine in rapidly proliferating cells or in hyperplastic tissue (1). Transient hyperuricemia, hyperuricosuria and acute gouty arthritis have occurred during liver extract induced reticulocytosis and during the therapy for deficiencies of folic acid or iron (1–4). To further explore the acute alterations of purine metabolism, we have investigated 7 patients with severe megaloblastic anemia for changes of uric acid metabolism and 3 important erythrocyte enzymes of purine metabolism (5).
KeywordsUric Acid Serum Uric Acid Purine Metabolism Megaloblastic Anemia Plasma Uric Acid
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