Protein Adsorption to Monosodium Urate Crystals: Differential Responses of Human Peripheral Blood Neutrophils
In order for acute gouty arthritis to occur, neutrophils must interact with monosodium urate (MSU) crystals. As a result of this interaction, enzymes, chemotactic factors, and other mediators of the inflammatory response are released from neutrophil lysosomes . We have observed previously that MSU crystals adsorb gamma globulin, albumin, and other proteins found in serum and joint fluid . This study was designed to demonstrate the effects of coating of MSU crystals with proteins on the phlogistic responses of neutrophils to crystals.
KeywordsHuman Serum Albumin Incubation Medium Lysosomal Enzyme Calcium Pyrophosphate Monosodium Urate
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