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Suppression of Experimental Urate Nephropathy by Salicylate

  • J. R. Klinenberg
  • R. Bluestone
  • J. Waisman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

An experimental model for sustained hyperuricemia, uricosuria and associated nephropathy was produced by feeding rats a potent uricase inhibitor — sodium oxonate, together with dietary supplements of uric acid (1,2). In both human gouty nephropathy and in this experimental hyperuricemic nephropathy in rats, deposition of crystalline materials within the renal tubules and parenchyma have been observed (3). The deposition of urate crystals in the kidney could account for many of the inflammatory features of human gouty nephropathy, but the absence of a satisfactory experimental model has precluded detailed study of this possible relationship.

Keywords

Uric Acid Interstitial Nephritis Serum Urate Interstitial Inflammation Urate Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Johnson, W.J., Stavric, B., Chartrand, A.: Uricase inhibition in the rat by S-triazines. An animal model for hyperuricemia and hyperuricosuria. Proc. Soc. Exp. Biol. Med. 131: 8, 1969.PubMedGoogle Scholar
  2. 2.
    Waisman, J., Bluestone, R., Klinenberg, J.: A prelminary report of nephropathy in hyperuricemic rats. Lab. Invest. 30: 716–722, 1974.PubMedGoogle Scholar
  3. 3.
    Bluestone, R., Brady, S., Waisman, J., and Klinenberg, J.R.: Experimental hyperuricemic nephropathy: A model for human urate deposition disease. Arth. Rheum. 18: 823–834, 1975.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. R. Klinenberg
    • 1
    • 2
  • R. Bluestone
    • 1
    • 2
  • J. Waisman
    • 1
    • 2
  1. 1.Departments of MedicineCedars-Sinai Medical Center and UCLA School of MedicineLos AngelesUSA
  2. 2.Medical & Research ServiceVA Wadsworth Hosp. CenterLos AngelesUSA

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