A Relationship between Free Urate, Protein-Bound Urate, Hyperuricemia and Gout in Caucasians and Maoris
Since clinical gout is characteristically associated with intra-articular urate crystals in hyperuricemic patients, much of the investigation into the pathogenesis of gout has involved studying the causes and effects of urate deposition (1). We have previously demonstrated that approximately 20% of urate in serum is bound to albumin (2). If the serum urate concentration per se is of paramount importance in the pathogenesis of gouty arthritis, then one would expect that in gouty subjects the free urate fraction should be elevated. It thus became of interest to determine the actual free concentration of urate in patients with gout and to compare this to the concentration of free urate in normal subjects and in patients with asymptomatic hyperuricemia.
KeywordsSerum Urate Gouty Arthritis Urate Concentration Caucasian Group Serum Urate Concentration
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