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A Relationship between Free Urate, Protein-Bound Urate, Hyperuricemia and Gout in Caucasians and Maoris

  • J. R. Klinenberg
  • D. S. Campion
  • R. W. Olsen
  • D. Caughey
  • R. Bluestone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

Since clinical gout is characteristically associated with intra-articular urate crystals in hyperuricemic patients, much of the investigation into the pathogenesis of gout has involved studying the causes and effects of urate deposition (1). We have previously demonstrated that approximately 20% of urate in serum is bound to albumin (2). If the serum urate concentration per se is of paramount importance in the pathogenesis of gouty arthritis, then one would expect that in gouty subjects the free urate fraction should be elevated. It thus became of interest to determine the actual free concentration of urate in patients with gout and to compare this to the concentration of free urate in normal subjects and in patients with asymptomatic hyperuricemia.

Keywords

Serum Urate Gouty Arthritis Urate Concentration Caucasian Group Serum Urate Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Klinenberg, J.R., Bluestone, R., Schlosstein, L., Waisman, J., and Whitehouse, M.W.: Urate deposition disease. How is it regulated and how can it be modified? Ann. Int. Med. 78: 99–111, 1973.PubMedGoogle Scholar
  2. 2.
    Campion, D.S., Bluestone, R., and Klinenberg, J.R.: Uric Acid: Characterization of its interaction with human serum albumin. J. Clin. Invest. 52: 2383–2386, 1973.PubMedCrossRefGoogle Scholar
  3. 3.
    Prior, I.A.M., Rose, B.S., and Davidson, F.: Metabolic abnormalities in New Zealand Maoris. Brit. Med. J. 1: 1065, 1964.PubMedCrossRefGoogle Scholar
  4. 4.
    Liddle, L., Seegmiller, J.E., and Laster, L.: The enzymatic spectrophotometric method for determination of uric acid. J. Lab. Clin. Med. 54: 903, 1959.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. R. Klinenberg
    • 1
    • 2
  • D. S. Campion
    • 1
    • 2
  • R. W. Olsen
    • 1
    • 2
  • D. Caughey
    • 1
    • 2
  • R. Bluestone
    • 1
    • 2
  1. 1.Departments of MedicineCedars-Sinai Medical Center and UCLA School of MedicineLos AngelesUSA
  2. 2.Medical & Research ServiceVA Wadsworth Hosp. CenterLos AngelesUSA

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