The Effect of Urine Flow Rate on Urate Clearance
The concept of renal clearance implies that the relationship between the excretion of a substance in the urine and its plasma concentration are such that the clearance is independent of the rate of urine flow, above a certain minimum value. Personal observation of consecutive hourly clearances of urate and creatinine often revealed more variation in the urate clearance than in the creatinine clearance, and this seemed greatest when there was fluctuation in the urine flow rate. At such times, one was left with the impression that an increase in the urine flow rate was followed by a delayed increase in the urate clearance. Brøchner-Mortenson (1937) had noted that urate excretion, and the urate clearance, fell when the urine flow rate was reduced below 1 ml/minute but detected no augmentation of the urate clearance with further increases in the urine flow rate above this. For these reasons, it was decided to look specifically at the effect of variation in urine flow rate as induced by a water diuresis upon urate excretion and urate clearance.
KeywordsCreatinine Clearance Renal Clearance Urine Flow Urine Flow Rate Inulin Clearance
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- 1.BRØCHNER-MORTENSEN, K. Acta Med. Scand., Supp 84:167 (1937).Google Scholar