Uptake of Hypoxanthine in Human Erythrocytes

  • M. M. Müller
  • G. Falkner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)


The concentration of oxypurines in the plasma is known to be rather low (10 – 40 μM) (6). Since the formation of purines is accomplished to a great extent by the liver (7, 8), a transport of purines by erythrocytes from liver to tissues with limited or no capacity of de novo purine synthesis has been postulated (1, 3). For this function erythrocytes should possess the ability to perform a fast uptake and release of these purines operating selectively under different conditions.


Uric Acid Incubation Medium Human Erythrocyte Purine Metabolism Purine Synthesis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Henderson J. F., Le Page G. A. (1959) J. Biol. Chem. 234, 3219.PubMedGoogle Scholar
  2. 2.
    Klingenberg M., Pfaff E. (1967) In Methods of Enzymology, eds. Colowick S. P., Kaplan N. O., Vol. 10, p. 680, Academic Press.Google Scholar
  3. 3.
    Lajtha L. G., Vane J. R. (1958) Nature 182, 191.PubMedCrossRefGoogle Scholar
  4. 4.
    Lassen U. V. (1967) Biochim. Biophys. Acta 135, 146.PubMedCrossRefGoogle Scholar
  5. 5.
    Lassen U.V. (1972) In “Oxygen Affinity of Hemoglobin and Red Cell Acid Base Status”, eds. Astrup P., Rorth M., p. 291, Academic Press, New York.Google Scholar
  6. 6.
    Orsulak P. J., Haab W., Appleton M. D. (1968) Analyt. Biochem. 23, 156.PubMedCrossRefGoogle Scholar
  7. 7.
    Pritchard J. B., Chavez-Peon F., Berlin R. D. (1970) Fed. Proc. Fed. Amer. Soc. Exp. Biol. 29, 799.Google Scholar
  8. 8.
    Sano L., Gamo T., Kakimoto Y., Taniguchi K., Takesada M., Nishinuma K. (1959) Biochim. Biophys. Acta 32, 586.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • M. M. Müller
    • 1
  • G. Falkner
    • 1
  1. 1.1st Department of Medical ChemistryUniversity of ViennaAustria

Personalised recommendations