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Control of Net Cellular Uptake of Adenosine from the Lumen Side of the Guinea Pig Jejunal Epithelium

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Purine Metabolism in Man—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 76B))

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Abstract

The mechanism of intestinal purine absorption is not well defined. The assumption that nucleotides are not able to permeate cell membranes renders nucleosides and nucleo-bases as the only chemical forms for the absorption of the purine moiety. While some although contraversial reports exist on the intestinal permeation of purine bases (Schanker et al., 1963; Oh et al., 1967; Berlin and Hawkins, 1968; Khan et al., 1975), no data are available concerning the absorptive mechanism of purine nucleosides. Therefore we investigated this problem focusing the main interest on the permeation process of adenosine.

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References

  • Agarwal, R.P. and Parks, Jr., R.E. (1975): A possible association between the nucleoside transport system of human erythrocytes and adenosine deaminase. Biochem. Pharmacol. 24, 547.

    Article  PubMed  CAS  Google Scholar 

  • Baer, H.P., Drummond, I. and Gillis, J. (1968): Studies on the specificity and mechanism of action of adenosine deaminase. Arch.Biochem.Biophys. 123, 172.

    Article  PubMed  CAS  Google Scholar 

  • Berlin, R.D. and Hawkins, R.A. (1968): Secretion of purines by the small intestine: general characteristics. Am.J. Physiol. 215, 932.

    PubMed  CAS  Google Scholar 

  • Berlin, R.D. and Hawkins, R.A. (1968): Secretion of purines by the small intestine: transport mechanism. Am.J. Physiol. 215, 942.

    PubMed  CAS  Google Scholar 

  • Cory, J.G. and Suhadolnik, R.J. (1965): Structural requirements of nucleosides for binding by adenosine deaminase. Biochemistry 4, 1729.

    Article  Google Scholar 

  • Khan, A.H., Wilson, S. and Crawhall, J.C. (1975): The influx of uric acid and other purines into everted jejunal sacs of the rat and hamster. Can. J. Physiol. Pharmacol. 53, 113.

    Article  PubMed  CAS  Google Scholar 

  • Kolassa, N., Roos, H. and Pfleger, K. (1972): A separation of purine derivatives by thin-layer chromatography on silica gel plates suitable for metabolic studies. J.Chromatogr. 66, 175.

    Article  PubMed  CAS  Google Scholar 

  • Lauterbach, F. (1975): Resorption und Sekretion von Arzneistoffen durch die Mukosaepithelien des Gastrointestinaltraktes. Arzneim.-Forsch. (Drug Res.) 25, 479.

    CAS  Google Scholar 

  • Oh, J.B., Dossetor, J.H. and Beck, I.T. (1967): Kinetics of uric acid transport and its production in rat small intestine. Can.J.Physiol.Pharmacol. 45, 121.

    Article  PubMed  CAS  Google Scholar 

  • Olsson, R.A., Snow, J.A., Gentry, M.K. and Frick, G.P. (1972): Adenosine uptake by canine heart. Circ.Res. 31, 767.

    Article  PubMed  CAS  Google Scholar 

  • Paterson, A.R.P. and Oliver, J.M. (1971): Nucleoside transport, II. Inhibition by p-nitrobenzylthioguanosine and related compounds. Can.J.Biochem. 49, 271.

    PubMed  CAS  Google Scholar 

  • Schanker, L.S., Jeffrey, J.J. and Tocco, D.J. (1963): Interaction of purines with the pyrimidirie transport process of the small intestine. Biochem.Pharmacol. 12, 1047

    Article  PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Kolassa, N., Stengg, R., Turnheim, K. (1977). Control of Net Cellular Uptake of Adenosine from the Lumen Side of the Guinea Pig Jejunal Epithelium. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology, vol 76B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3285-5_18

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  • DOI: https://doi.org/10.1007/978-1-4684-3285-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3287-9

  • Online ISBN: 978-1-4684-3285-5

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