Effects of Drugs on the Uptake of Uric Acid by Separated Renal Tubules of the Rabbit

  • Ian Kippen
  • James R. Klinenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)


The effects of various compounds on the transport of uric acid by rabbit kidney have been investigated in several previous studies. Experiments utilizing clearance techniques have established that uric acid clearance is reduced by probenecid, salicylate, PAH, chlorothiazide and a number of other compounds (1,2). Stop-flow analysis has indicated that probenecid reduces uric acid clearance by blocking its secretion in the proximal tubule (3).


Uric Acid Salicylic Acid Sodium Salicylate Uric Acid Concentration Ethacrynic Acid 
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  1. 1.
    Poulsen, H.: Inhibition of uric acid excretion in rabbits given probenecid or salicylic acid. Acta Pharmacol. Toxicol. 11:277–286, 1955.CrossRefGoogle Scholar
  2. 2.
    Høller, J.V.: Clearance experiments on the effect of probenecid on urate excretion in the rabbit. Acta Pharmacol. Toxicol. 23:321–328, 1965.Google Scholar
  3. 3.
    Beechwood, E.C., Berndt, W.O. and Mudge, G.H.: Stop-flow analysis of tubular transport of uric acid in rabbits. Am. J. Physiol. 207:1265–1272, 1964.PubMedGoogle Scholar
  4. 4.
    Platts, M.M. and Mudge, G.H.: Accumulation of uric acid by slices of kidney cortex. Am. J. Physiol. 200:387–391, 1961.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Ian Kippen
    • 1
  • James R. Klinenberg
    • 1
  1. 1.Departments of Pharmacology and Medicine, UCLA, School of Medicine, and Department of MedicineCedars-Sinai Medical CenterLos AngelesUSA

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