Effects of Drugs on the Uptake of Uric Acid by Separated Renal Tubules of the Rabbit
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 76B)
The effects of various compounds on the transport of uric acid by rabbit kidney have been investigated in several previous studies. Experiments utilizing clearance techniques have established that uric acid clearance is reduced by probenecid, salicylate, PAH, chlorothiazide and a number of other compounds (1,2). Stop-flow analysis has indicated that probenecid reduces uric acid clearance by blocking its secretion in the proximal tubule (3).
KeywordsUric Acid Salicylic Acid Sodium Salicylate Uric Acid Concentration Ethacrynic Acid
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© Plenum Press, New York 1977