Some Characteristics of Uric Acid Uptake by Separated Renal Tubules of the Rabbit
Uric acid is generally believed to be both secreted and reabsorbed by the mammalian renal proximal tubule. The degree to which reabsorption and secretion take place is highly species dependent. Uric acid uptake by slices of rabbit renal cortex has been used by previous investigators as a model of secretory transport of this compound. In 1961, Platts and Mudge (1) demonstrated that uptake of uric acid into rabbit kidney cortical slices is influenced by a variety of factors including hypoxia and the presence of various metabolic substrates and drugs. Berndt and Beechwood (2) subsequently showed that this uptake was pH dependent, and was influenced by the medium concentrations of sodium and potassium. Both groups of investigators obtained uric acid slice to medium ratios of approximately 2.5 indicating concentrative uptake of uric acid.
KeywordsCitrate Pyruvate Luminal Succinate Purine
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- 1.Platts, M.M. and Mudge, G.H.: Accumulation of uric acid by slices of kidney cortex. Am. J. Physiol. 200:387–391, 1961.Google Scholar