Abstract
Uric acid is generally believed to be both secreted and reabsorbed by the mammalian renal proximal tubule. The degree to which reabsorption and secretion take place is highly species dependent. Uric acid uptake by slices of rabbit renal cortex has been used by previous investigators as a model of secretory transport of this compound. In 1961, Platts and Mudge (1) demonstrated that uptake of uric acid into rabbit kidney cortical slices is influenced by a variety of factors including hypoxia and the presence of various metabolic substrates and drugs. Berndt and Beechwood (2) subsequently showed that this uptake was pH dependent, and was influenced by the medium concentrations of sodium and potassium. Both groups of investigators obtained uric acid slice to medium ratios of approximately 2.5 indicating concentrative uptake of uric acid.
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References
Platts, M.M. and Mudge, G.H.: Accumulation of uric acid by slices of kidney cortex. Am. J. Physiol. 200:387–391, 1961.
Berndt, W.O. and Beechwood, E.C.: Influence of inorganic electrolytes and ouabain on uric acid transport Am. J. Physiol. 208:642–648, 1965.
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Murthy, L. and Foulkes, E.C.: Movement of solutes across luminal cell membranes in kidney tubules of the rabbit. Nature 213:180–181, 1967.
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© 1977 Plenum Press, New York
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Kippen, I., Klinenberg, J.R. (1977). Some Characteristics of Uric Acid Uptake by Separated Renal Tubules of the Rabbit. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology, vol 76B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3285-5_15
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DOI: https://doi.org/10.1007/978-1-4684-3285-5_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3287-9
Online ISBN: 978-1-4684-3285-5
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