Sites of Urate Transport in the Rat Nephron
The rat has been used frequently for studying renal urate excretion (1–14, 16). This is clearly correlated with the fact that the overall renal handling of urate in this animal is comparable to that in man (5). Previous clearance studies have revealed that the net reabsorption of urate in the mammalian nephron is the result of bidirectional tubular transport (17). Recently several investigators have applied different micropuncture and microanalytical methods to the rat model to further elucidate the complicated pattern of bidirectional tubular transport (1, 3, 4, 7–10, 13, 14, 16). As a result of these studies, it is generally accepted that both a secretory and a reabsorptive mechanism for urate exist in the proximal tubule. In the distal nephron very little, if any, urate is transported. However, some controversy still remains concerning the quantitative correlation of reabsorption and secretion in the proximal tubule and the quantitative importance of the post-proximal reabsorption, i.e. loop reabsorption (14).
KeywordsUric Acid Proximal Tubule Distal Convoluted Tubule Distal Nephron Nephron Segment
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