Introduction of Artificial Crosslinks into Proteins

Uy, Rosa; Wold, Finn

doi:10.1007/978-1-4684-3282-4_9

Introduction of Artificial Crosslinks into Proteins

Rosa Uy² &
Finn Wold²

Chapter

379 Accesses
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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 86A))

Abstract

In this chapter, we present a brief overview of the current status of protein crosslinking technology. An attempt is made to compare the natural crosslinks and natural crosslinking agents to the artificial ones, and a brief section is devoted to the potential use of enzymes (transglutaminase and peroxidase) as cross-linking agents in vitro. Homobifunctional (x-R-x) and heterobifunctional (x-R-y) reagents are considered in terms of the kinds of functional groups and R-groups that have been used in protein crosslinking, and some examples of reagents and applications from the recent literature are tabulated.

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References

Barthing, G. J., Chattopadhyay, S. K., Barker, C. W., Forrester, L. J. and Brown, H. D. (1974) Int. J. Peptide Protein Res. 6,287.
Article Google Scholar
Bechet, J. J., Dupaix, A. and Yon, J. (1973) Eur. J. Biochem. 35, 527.
Article PubMed CAS Google Scholar
Bello, J. and Bello, H. R. (1976) Arch. Biochem. Biophys. 172, 608.
Article PubMed CAS Google Scholar
Benesch, R. and Benesch, R. E. (1956) J. Am. Chem. Soc. 78, 1597.
Article CAS Google Scholar
Benesch, R., Ikeda, T. and Benesch, R. E. (1976) J. Biol. Chem. 251, 465.
PubMed CAS Google Scholar
Boesel, R. W. and Carpenter, F. H. (1970) Biochem. Biophys. Res. Commun. 38, 678.
Article PubMed CAS Google Scholar
Brandenburg, D. (1972) Hoppe-Seyler’s Z. Physiol. Chem. 353, 869.
Article PubMed CAS Google Scholar
Brenner, S. C. (1976) Ph.D. Thesis, University of Minnesota
Google Scholar
Brewer, G. J. and Singer, S. J. (1975) Biochemistry 13, 3580.
Google Scholar
Busse, W. D. and Carpenter, F. H. (1974) J. Am. Chem. Soc. 96, 5947.
Article PubMed CAS Google Scholar
Chang, F. N. and Flaks, J. G. (1972) J. Mol. Biol. 68, 177.
Article PubMed CAS Google Scholar
Chung, S. I. and Folk, J. E. (1975) Fed. Proc. 34, 259.
Google Scholar
Clarke, D. D., Mycek, M. J., Neidle, A. and Waelsch, H. (1959) Arch. Biochem. Biophys. 79, 338.
Article CAS Google Scholar
Coggins, J. R., Hooper, E. A. and Perham, R. N. (1976) Biochemistry 15, 2527.
Google Scholar
Cooke, R. D. and Holbrook, J. J. (1974) Biochem. J. 141, 71.
PubMed CAS Google Scholar
Davies, G. E. and Stark, G. R. (1970) Proc. Nat. Acad. Sci. U.S. 66, 651.
Google Scholar
Dutton, A. and Singer, S. J. (1975) Proc. Nat. Acad. Sci. U.S. 72, 2568.
Article CAS Google Scholar
Fasold, H. (1965) Biochem. Z. 342, 295.
PubMed CAS Google Scholar
Fasold, H., Groschel-Stewart, U. and Turba, F. (1964) Biochem. Z. 339, 487.
Google Scholar
Fasold, H., Klappenberger, J., Meyer, C. and Remold, H. (1971) Angew. Chem. Int. Ed. Engl. 10, 795.
Article PubMed Google Scholar
Folk, J. E. and Chung, S. I. (1973) Adv. Enzymol. 38, 109.
PubMed CAS Google Scholar
Folk, J. E., Cole, P. W. and Mullooly, J. P. (1967) J. Biol. Chem. 242, 4329.
Google Scholar
Freeberg, W. B. and Hardman, J. K. (1971) J. Biol. Chem. 246, 1439.
Google Scholar
Geiger, R. and Obermeier, R. (1973) Biochem. Biophys. Res. Commun. 55, 60.
Google Scholar
Goodfriend, T. L., Levine, L. and Fasman, G. D. (1964) Science 144, 1344.
Article PubMed CAS Google Scholar
Grow, T. E. and Fried, M. (1975) Biochem. Biophys. Res. Commun. 66, 352.
Article PubMed CAS Google Scholar
Guire, P. (1976) Fed. Proc. 35, 1632.
Google Scholar
Hartman, F. C. and Wold, F. (1967) Biochemistry 6, 2439.
Article PubMed CAS Google Scholar
Herzig, D. J., Rees, A. W. and Day, R. A. (1964) Biopolymers 2, 349.
Article CAS Google Scholar
Hixson, S. H. and Hixson, S. S.(1975) Biochemistry 14, 4251.
Article PubMed CAS Google Scholar
Hucho, F., Müllner, H. and Sund, H. (1975) Eur. J. Biochem. 59, 79.
Article PubMed CAS Google Scholar
Husain, S. S., Ferguson, J. B. and Fruton, J. S. (1971) Proc. Nat. Acad. Sci. (U.S.) 68, 2765.
Article CAS Google Scholar
Husain, S. S. and Lowe, G. (1970) Biochemistry 117, 341.
CAS Google Scholar
Jen, L. C. (1967) Ph.D. Thesis, University of Illinois
Google Scholar
Ji, T. H. and Ji, I. (1974) J. Mol. Biol. 86, 129.
Article PubMed CAS Google Scholar
Josephs, R., Eisenberg, H. and Reisler, E. (1973) Biochemistry 12, 4060.
Article PubMed CAS Google Scholar
Kenny, J. W., Sommer, A. and Traut, R. R. (1975) J. Biol. Chem. 250, 9434.
PubMed CAS Google Scholar
Lindsay, D. G. (1971) FEBS Letters 21, 105.
Article Google Scholar
Lomant, A. J. and Fairbanks, G. (1976) J. Mol. Biol. 104, 243.
Article PubMed CAS Google Scholar
Lorand, L., Campbell, L. K. and Robertson, B. J. (1972) Biochemistry 11, 434.
Google Scholar
Lutter, L. C., Ortanderl, F. and Fasold, H. (1974) FEBS Letters 48, 288.
Article PubMed CAS Google Scholar
Macleod, R. M. and Hill, R. J. (1970) J. Biol. Chem. 245, 4875.
PubMed CAS Google Scholar
McKee, R. A., Schwartz, M. L., Pizzo, S. V. and Hill, R. L. (1972) Ann. N.Y. Acad. Sci. 202, 127.
Article PubMed CAS Google Scholar
Means, G. E. and Feeney, R. E. (1971) “Chemical Modification of Proteins”, Holden-Day, Inc. San Francisco, Cambridge, London, Amsterdam.
Google Scholar
Olomucki, M. and Diopoh, J. (1972) Biochim. Biophys. Acta 263, 213.
PubMed CAS Google Scholar
Patel, R. P. and Price, S. (1967) Biopolymers 5, 583.
Article CAS Google Scholar
Patramani, I., Katsiri, K., Pistevou, E., Kalogerakos, T., Pawlatos, M. and Evangelopoulos, A. E. (1969) Eur. J. Biochem. 11, 28.
Article PubMed CAS Google Scholar
Ruoho, A., Bartlett, P. A., Dutton, A. and Singer, S. J. (1975) Biochem. Biophys. Res. Commun. 63, 417.
Article PubMed CAS Google Scholar
Schick, A. F. and Singer, S. J. (1961) J. Biol. Chem. 236, 2477.
PubMed CAS Google Scholar
Silman, H. I., Albu-Weissenberg, M. and Katchalski, E. (1966) Biopolymers 4, 441.
Article PubMed CAS Google Scholar
Slobin, L. I. (1972) J. Mol. Biol. 64, 297.
Article PubMed CAS Google Scholar
Snyder, P. D., Wold, F., Bernlohr, R. W., Dollum, C., Desnick, R.J. Krivit, W. and Condie, R. M. (1974) Biochim. Biophys. Acta 350, 432.
Google Scholar
Sperling, J. and Havron, A. (1976) Biochemistry 15, 1489.
Article PubMed CAS Google Scholar
Staros, J. V. and Richards, F. M. (1974) Biochemistry 13, 2720.
Article PubMed CAS Google Scholar
Staros, J. V., Richards, F. M. and Haley, B. E. (1975) J. Biol. Chem. 250, 8174.
PubMed CAS Google Scholar
Steck, T. L. (1972) J. Mol. Biol. 66, 295.
Article PubMed CAS Google Scholar
Sun, T. T., Traut, R. R. and Kahan, L. (1974) J. Mol. Biol. 87, 509.
Article PubMed CAS Google Scholar
Tinberg, H. M., Nayndu, P.R.V. and Packer, L. (1976) Arch. Biochem. Biophys. 172, 734.
Article PubMed CAS Google Scholar
Toda, H. and Folk, J. E. (1969) Biochim. Biophys. Acta 175, 427.
PubMed CAS Google Scholar
Uy, R. and Wold, F. (1976) in “Biomedical Applications of Immobilized Enzymes and Proteins”, T.M.S. Chang, ed., Plenum Publishing Corporation, New York, N.Y.
Google Scholar
Wang, K. and Richards, F. M. (1974) J. Biol. Chem. 249, 8005.
PubMed CAS Google Scholar
Wang, K. and Richards, F. M. (1975) J. Biol. Chem. 250, 6622.
PubMed CAS Google Scholar
Wajda, I. J., Hanbauer, I., Manigault, I. and Lajtha, A. (1971) Biochem. Pharmacol. 20, 3197.
Article PubMed CAS Google Scholar
Wetz, K., Fasold, H. and Meyer, C. (1974) Anal. Biochem. 58, 347.
Article PubMed CAS Google Scholar
Wold, F. (1961) J. Biol. Chem. 236, 106.
PubMed CAS Google Scholar
Wold, F. (1972) in “Meth. in Enzymol.”, C.H.W. Hirs and S. N. Timasheff, eds., Vol. 25B, p. 623.
Google Scholar
Wolf, B., Lesnaw, J. A. and Reichman, M. E. (1970) Eur., J. Biochem. 13, 519.
Google Scholar
Wu, C.-W., Yarbrough, L. R. and Wu, F.Y.H. (1976) Biochemistry 15, 2863.
Article PubMed CAS Google Scholar
Yaqub, M. and Guire, P. (1974) J. Biomed. Mater. Res. 8, 291.
Article PubMed CAS Google Scholar
Zaborsky, O. R. (1976) in “Biomedical Applications of Immobilized Enzymes and Proteins”, T.M.S. Chang, ed., Plenum Publishing Corporation, New York, N.Y.
Google Scholar
Zahn, H. (1955) Proc. International Wool Textile Research Conf., Australia C-425.
Google Scholar
Zahn, H. and Meienhofer, J. (1958) Makromol. Chem. 26, 153.
Article CAS Google Scholar

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Department of Biochemistry, University of Minnesota, St. Paul, MN, 55108, USA
Rosa Uy & Finn Wold

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Rosa Uy
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Finn Wold
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Western Regional Research Laboratory, Agricultural Research Service U.S. Department of Agriculture, Berkeley, California, USA
Mendel Friedman

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Uy, R., Wold, F. (1977). Introduction of Artificial Crosslinks into Proteins. In: Friedman, M. (eds) Protein Crosslinking. Advances in Experimental Medicine and Biology, vol 86A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3282-4_9

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DOI: https://doi.org/10.1007/978-1-4684-3282-4_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3284-8
Online ISBN: 978-1-4684-3282-4
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