Ionizing Radiation-Induced Crosslinking in Proteins

  • Osamu Yamamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 86A)


A number of reports describe effects of ionizing radiation on proteins both in solid state and in solution. Such studies have been done mainly in relation to inactivation of enzymes (Augenstein, 1962, 1964; Luse, 1964; Dale, 1966; Garrison, 1968). Recently Grossweiner (1976) reviewed photochemical and radiochemical reactions for enzyme inactivation. These reports discuss aggregation, chain cleavage, opening and interchange of disulfide linkages, production and disappearance of sulfhydryl groups, decomposition of amino acid residues, and their negative responses. the diversity of the results presented makes it difficult to generalize about mechanism of radiation-induced transformation. Various factors are involved in the radiation-induced crosslink-formation in proteins.


Human Serum Albumin Disulfide Bond Aromatic Amino Acid Specific Amino Acid Electron Spin Resonance Study 


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Osamu Yamamoto
    • 1
  1. 1.Research Institute for Nuclear Medicine and BiologyHiroshima UniversityHiroshimaJapan

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