Protein: Polyanion Interactions. Studies on the Trehalose-P Synthetase as a Model System

  • Alan D. Elbein
  • Y. T. Pan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 86A)


The interaction of proteins with various types of polyelectrolytes occurs commonly in nature. in the case of enzymes, the interaction may be quite specific with regard to the nature of the polyelectrolyte. the addition of the polyelectrolyte to an enzyme may result in either an increase in enzyme activity or an inhibition of activity depending on the enzyme in question. Thus, polyanions such as polynucleotides, or sulfated glycoaminoglycans like heparin and chondroitin sulfate, may be activators of some enzymes but are inhibitors of others. A similar situation apparently applies to polycations such as polylysine or polyornithine. There are apparently two important requirements for these polyelectrolytes to be enzyme effectors: 1) the macromolecular nature of the polyelectrolyte and 2) the presence of strong positive or negative charges (1).


Hyaluronic Acid Chondroitin Sulfate Incubation Mixture Sugar Nucleotide Mycobacterium Smegmatis 


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Alan D. Elbein
    • 1
  • Y. T. Pan
    • 1
  1. 1.Department of BiochemistryUniversity of Texas Health Science CenterSan AntonioUSA

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