Mechanisms by Which Small Molecules Alter Ionic Permeability Through Lipid Bilayer Membranes

  • Gabor Szabo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 84)

Abstract

Small molecules may be particularly effective cytotoxic agents by way of altering ionic permeability in cell and organelle membranes. The mechanisms by which such molecules may act on membrane permeability are examined here in light of the rather precise understanding of the mechanisms by which ionic permeability is induced and altered in lipid bilayer membranes. In particular, the influence of specific changes in membrane composition on the kinetics of direct and carrier mediated transport of ions are examined in detail and related to the electrical potentials originating from dipolar residues at the membrane surface.

Keywords

Cholesterol Sugar Permeability Toxicity Hydrocarbon 

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Gabor Szabo
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Texas Medical BranchGalvestonUSA

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