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Membrane Water Channels and SH-Groups

  • R. I. Sha’afi
  • M. B. Feinstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 84)

Abstract

The transport of water across human red cell membranes is commonly interpreted in terms of small aqueous channels. This interpretation is based largely on indirect evidence. In this report, two sets of experiments providing more direct evidence for this idea is presented.
  1. (1)

    The effect of various SH-reactive reagents on the movement of water was studied. Using these compounds we attempted to localize and characterize those membrane SH-groups which are important for water transport.

     
  2. (2)

    Experimental evidence which suggests that these channels are assembled from aggregates of specific membrane protein(s) is presented.

     

Keywords

Water Transport Erythrocyte Membrane Protein Phenyl Sulfonate Thiosalicylic Acid Phenylmercuric Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. I. Sha’afi
    • 1
  • M. B. Feinstein
    • 1
  1. 1.University of Connecticut Health CenterFarmingtonUSA

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