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On the Nature of the Transport Pathway Used for Ca-Dependent K Movement in Human Red Blood Cells

  • Joseph F. Hoffman
  • Ronald M. Blum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 84)

Abstract

This paper is concerned with the mechanism by which energy-depleted human red cells become permeable to K (but not to Na) when they are exposed to Ca. In an attempt to distinguish a diffusion from a mediated process competitive type effects of different ions and their sidedness of action on K transport are considered as well as the action of certain transport inhibitors. While the nature of the interactions implies the involvement of a mediated process (perhaps an altered form of the Na:K pump apparatus) more direct evidence will be needed to make a definitive assessment.

Keywords

Hypertonic Medium Depletion Time Human Erythrocyte Ghost Thin Lipid Membrane Pump Apparatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Joseph F. Hoffman
    • 1
  • Ronald M. Blum
    • 1
  1. 1.Department of Physiology, School of MedicineYale UniversityNew HavenUSA

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