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Cell Membranes in Cytotoxicity

  • A. C. Allison
  • J. Ferluga
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 84)

Abstract

Silica particles are cytotoxic for macrophages because they damage the membranes around secondary lysoscmes in which the particles are engulfed. Hydroxyl groups of silicic acid on the surface of the particles form hydrogen bonds with phosphate ester groups of phospholipids and disrupt a variety of natural and artificial membranes. Asbestos fibers induce secretion of hydrolytic enzymes from cultured macrophages. Magnesium hydroxide groups of chrysotile asbestos interact ionically with ionized sialic acid residues of membrane glycoproteins, increase passive cation flux and produce osmotic lysis. The terminal carponents of complement (C5b-C9) when inserted into the bi layer structure also increase passive cation flux and produce osmotic lysis. The small catplement cleavage product C3a is lytic for several cell types, especially malignant cells. The mechanism by which specifically sensitized thymus-derived (T)-lymphocytes kill tumour cells is discussed. Plasma membranes frcm effector lymphocytes possess considerable cytolytic potential, which is dependent on the activity of a membrane-associated proteinase.

Keywords

Silica Particle Silicic Acid Sialic Acid Residue Sendai Virus Asbestos Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. C. Allison
    • 1
  • J. Ferluga
    • 1
  1. 1.Clinical Research CentreHarrowEngland

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