Saturated and Mono-Unsaturated Fatty Acid Biosynthesis in Brain: Relation to Development in Normal and Dysmyelinating Mutant Mice

  • J. M. Bourre
  • S. Pollet
  • M. Paturneau-Jouas
  • N. Baumann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


Fatty acids, constituents of most lipids, play a key role in membrane structure and function. Very long chain fatty acids, either saturated or mono-unsaturated are necessary to myelin; therefore, their biosynthesis is fundamental for normal brain maturation. Identification of some of the biosynthetic pathways has been facilitated by the use of mutant mice (Quaking and Jimpy) characterized by a defective myelination (1) and deficient in very long chain fatty acids (2, 3).


Chain Fatty Acid Fatty Acid Biosynthesis Acyl Donor Lignoceric Acid Fatty Acid Elongation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. M. Bourre
    • 1
  • S. Pollet
    • 1
  • M. Paturneau-Jouas
    • 1
  • N. Baumann
    • 1
  1. 1.Laboratoire de NeurochimieHôpital de la SalpêtrièreParis Cédex 13France

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