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Regulatory Function of Δ6 Desaturase — Key Enzyme of Polyunsaturated Fatty Acid Synthesis

  • R. R. Brenner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)

Abstract

Polyunsaturated fatty acids are synthesized in animals by a sequence of desaturation and elongation reactions which, as we know now, follow special rules. The starting substrates are CoA thioesters of palmitoleic, oleic, linoleic and α linolenic acids. The acyl-CoA synthesis is faster than elongation or desaturation reactions (Marcel and Suzue, 1972). The enzymes involved in the elongation are found either in the endoplasmic reticulum or in mitochondria but the specificity of each group is different. The microsomal system prefers Δ6 unsaturated acyl-CoA and hexanoyl CoA whereas the mitochondrial prefers medium chain acyl-CoA (Podack et al, 1974; Hinsch and Seubert, 1975).

Keywords

Desaturase Activity Essential Fatty Acid Deficiency Desaturation Activity Double Bond Index Dietary Glucose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Actis Dato S. M., Catala A. & Brenner R. R. (1973) Lipids 8, 1–6PubMedCrossRefGoogle Scholar
  2. Alaniz M. J. T. de & Brenner R. R. (1976) Mol. and Cell Biochem. in pressGoogle Scholar
  3. Alaniz M. J. T. de, Gomez Dumm, I. N. T. de & Brenner R. R. (1976) Mol. and Cell Biochem. 12, 3–8CrossRefGoogle Scholar
  4. Alaniz M. J. T. de, Ponz G. & Brenner R. R. (1975) Acta Physiol. Latinoam. 25, 3–13Google Scholar
  5. Ayala S., Gaspar G., Brenner R. R., Peluffo R. O. & Kunau W. (1973) J. Lipid Res. 14, 296–305PubMedGoogle Scholar
  6. Bernert J. T. Jr & Sprecher H. (1975) Biochim. Biophys. Acta 398, 354–363PubMedGoogle Scholar
  7. Brenner R. R. (1974) Mol. and Cell Biochem. 3, 41–52CrossRefGoogle Scholar
  8. Brenner R. R. & Catala A. (1971) Lipids 6, 873–881PubMedCrossRefGoogle Scholar
  9. Brenner R. R. & Nervi A. M. (1965) J. Lipid Res. 6, 363–368PubMedGoogle Scholar
  10. Brenner R. R. & Peluffo R. O. (1966) J. Biol. Chem. 241, 5213–5219PubMedGoogle Scholar
  11. Brenner R. R. & Peluffo R. O. (1969) Biochim. Biophys. Acta 176, 471–479PubMedGoogle Scholar
  12. Brenner R. R., Peluffo R. O., Mercuri O. and Restelli M. A. (1968) Amer. J. Physiol. 215, 63–70PubMedGoogle Scholar
  13. Castuma J. C., Catala A., Brenner R. R. & Christie W. W. (1974) Acta Physiol. Latinoam. 24, 31–39Google Scholar
  14. Catala A., Nervi A. M. & Brenner R. R. (1975) J. Biol. Chem. 250, 7481–7484PubMedGoogle Scholar
  15. Dunbar L. M. & Bailey J. M. (1975) J. Biol. Chem. 250, 1152–1153Google Scholar
  16. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1970) J. Lipid Res. 11, 96–101PubMedGoogle Scholar
  17. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1975) J. Lipid Res. 16, 264–268PubMedGoogle Scholar
  18. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1976) J. Lipid Res. 17, 616–621PubMedGoogle Scholar
  19. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. Lipids in pressGoogle Scholar
  20. Gomez Dumm I. N. T. de, Peluffo R. O. & Brenner R. R. (1972) Lipids 7, 590–592CrossRefGoogle Scholar
  21. Hinsch W. & Seubert W. (1975) Eur. J. Biochem. 53, 437–447PubMedCrossRefGoogle Scholar
  22. Marcel Y., Christiansen K. & Holman R. (1968) Biochim. Biophys. Acta 164, 25–34PubMedGoogle Scholar
  23. Marcel Y. & Suzue G. (1972) J. Biol. Chem., 247, 4433–4436PubMedGoogle Scholar
  24. Mercuri O., Peluffo R. O. & Brenner R. R. (1966) Biochim. Biophys. Acta 116, 409–411.PubMedGoogle Scholar
  25. Mercuri O., Peluffo R. O. & Brenner R. R. (1967) Lipids 2, 284–285PubMedCrossRefGoogle Scholar
  26. Nervi A. M., Brenner R. R. & Peluffo R. O. (1968) Biochim. Biophys. Acta 152, 539–551PubMedGoogle Scholar
  27. Nervi A. M., Catala A., Brenner R. R. & Peluffo R. O. (1975) Lipids 10, 348–352PubMedCrossRefGoogle Scholar
  28. Ninno R. E., Torrengo M. P. de, Castuma C. & Brenner R. R. (1974) Biochim. Biophys. Acta 360, 124–133PubMedGoogle Scholar
  29. Peluffo R. O. & Brenner R. R. (1974) J. Nutr. 104, 894–900PubMedGoogle Scholar
  30. Peluffo R. O., Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1971) J. Nutr. 101, 1075–1084PubMedGoogle Scholar
  31. Peluffo R. O., Nervi A. M. & Brenner R. R. (1976) 441, 25-31Google Scholar
  32. Podack E. R., Lakomek M., Saathoff G. A. & Seubert W. (1974) Eur. J. Biochim. 45, 13–23CrossRefGoogle Scholar
  33. Sprecher H. & Lee Ch. (1975) Biochim. Biophys. Acta 388, 113–125PubMedGoogle Scholar
  34. Torrengo M. P. de & Brenner R. R. (1976) Biochim. Biophys. Acta 424, 36–44PubMedGoogle Scholar
  35. Ullman D. & Sprecher H. (1971a) Biochim. Biophys. Acta 248, 61–70Google Scholar
  36. Ullman D. & Sprecher H. (1971b) Biochim. Biophys. Acta 248, 186–197PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. R. Brenner
    • 1
    • 2
  1. 1.Cátedra de Bioquímica, Instituto de Fisiología, Facultad de Ciencias MédicasUniversidad Nacional de La PlataLa PlataArgentina
  2. 2.Member of the Carrera del Investigador Científico del ConsejoNacional de Investigaciones Científicas y TécnicasArgentina

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