Effect of Thyroxine on Δ6 and Δ9 Desaturation Activity

  • I. N. T. de Gómez Dumm
  • M. J. T. de Alaniz
  • R. R. Brenner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


Many studies have revealed that thyroid hormones markedly affect lipid metabolism in man and in several species of animals. Concerning fatty acid biosynthesis it was demonstrated that the administration of thyroxine stimulates the incorporation of l–14c acetate into fatty acids in rats and mice (Dayton et al, 1960) (Gompertz and Greenbaum, 1966) (Marchi and Mayer, 1959). According to Gompertz and Greenbaum (1966) these observations appear to be associated with an increase of stearyl-CoA desaturase activity. Moreover Myant and Iliffe (1963) found that rats treated with thyroxine showed an inhibition of acetate incorporation, but not of malonate incorporation, into fatty acids by mitochondria free, subcellular liver preparations. Other authors have shown that the thyrotoxic state was accompanied by an increased incorporation of acetyl-CoA to fatty acid and a rise in the activity of fatty acid synthetase in rat livers (Diamant et al, 1972) (Roncari and Murthy, 1975). However, in vitro studies of fatty acid synthesis in which liver supernatant of 105,000 xg and microsomal preparations were incubated with the hormone showed that thyroxine inhibits de novo synthesis of palmitate and stimulates the desaturation reactions (Faas et al, 1972).


Linoleic Acid Fatty Acid Synthetase Fatty Acid Desaturation Desaturation Activity Desaturation Reaction 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brenner R. R. (1971) Lipids 6, 567–575PubMedCrossRefGoogle Scholar
  2. Castuma J. C., Catala A. & Brenner R. R. (1972) J. Lipid Res. 13, 783–789.PubMedGoogle Scholar
  3. Dayton S., Dayton J., Drimmer F. & Kendall F. E. (1960) Am. J. Physiol. 199, 71–76PubMedGoogle Scholar
  4. Diamant S., Gorin E. & Shafrir E. (1972) Eur. J. Biochem., 26, 553–559PubMedCrossRefGoogle Scholar
  5. Dubowsky K. M. (1962) Clin. Chenu, 8, 215–235Google Scholar
  6. Ellefson R. D. & Mason H. L. (1964) Endocrinology 75, 179–186PubMedCrossRefGoogle Scholar
  7. Faas F. H., Carter W. J. & Wynn J. (1972) Endocrinology 91, 1481–1492PubMedCrossRefGoogle Scholar
  8. Folch J., Lees M. & Sloane-Stanley G. H. (1957) J. Biol. Chem. 226, 497–509PubMedGoogle Scholar
  9. Freeland R. A. (1965) Endocrinology 77, 19–27CrossRefGoogle Scholar
  10. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1975) J. Lipid Res. 16, 264–268PubMedGoogle Scholar
  11. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1976) J. Lipid Res. 17, 616–621PubMedGoogle Scholar
  12. Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. Lipids in pressGoogle Scholar
  13. Gompertz D. & Greenbaum A. L. (1966) Biochem. Biophys. Acta 116, 441–459PubMedGoogle Scholar
  14. Gornall A. G., Bardawill C. J. & David M. M. (1949) J. Biol. Chem. 117, 751–766Google Scholar
  15. Kirkeby K. (1972) Acta Endocrinol. 21, 62–72Google Scholar
  16. Marchi P. & Mayer J. (1959) Experientia 15, 359–361PubMedCrossRefGoogle Scholar
  17. Mato J. M. & Serrano Rios M. (1973) Rev. Esp. Fisiol. 29, 233–238PubMedGoogle Scholar
  18. Mercuri O., Peluffo R. O. & De Tomas M. E. (1974) Biochim. Biophys. Acta 369, 264–268PubMedGoogle Scholar
  19. Mitchel R. & Truchot R. (1962) Bull. Soc. Chim. Biol. 44, 1141–1152Google Scholar
  20. Myant N. B. & Iliffe J. (1963) in “The control of lipid metabolism” (J. K. Grant, ed.) p. 145–154. Academic Press, London and New YorkGoogle Scholar
  21. Nelson D. R. & Cornatzer W. E. (1965) Endocrinology 77, 37–44CrossRefGoogle Scholar
  22. Peluffo R. O., Gomez Dumm I. N. T. de, Alaniz M. J. T. de & Brenner R. R. (1971) J. Nutr. 101, 1075–1084PubMedGoogle Scholar
  23. Rabinowitz J. L. & Myerson R. M. (1967) Metab. Clin. Exp. 16, 68–75PubMedCrossRefGoogle Scholar
  24. Roncari D. & Murthy V. K. (1975) J. Biol. Chem. 250, 4134–4138PubMedGoogle Scholar
  25. Takahashi T. & Suzuki M. (1975) Endocrinol. Jap. 22, 187–194CrossRefGoogle Scholar
  26. Van Handel E. (1965) Anal. Biochem. 11, 256–265PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • I. N. T. de Gómez Dumm
    • 1
    • 2
  • M. J. T. de Alaniz
    • 1
    • 2
  • R. R. Brenner
    • 1
    • 2
  1. 1.Instituto de FisiologíaFacultad de Ciencias Médicas Universidad Nacional de La PlataLa PlataArgentina
  2. 2.Carrera del Investigador Científico of the Consejo Nacional de Investigaciones Científicas y TécnicasArgentina

Personalised recommendations