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Dietary Essential Fatty Acids, Brain Polyunsaturated Fatty Acids, and Prostaglandin Biosynthesis

  • C. Galli
  • G. Galli
  • C. Spagnuolo
  • E. Bosisio
  • L. Tosi
  • G. C. Folco
  • D. Longiave
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)

Abstract

The adult brain contains high levels of polyenoic fatty acids deriving from linoleic (18:2 Δ9,12 n — 6) and from linolenic acid (18:3 Δ9,12,15 n — 3). The two major polyunsaturated fatty acids (Pufa) present in brain are arachidonic acid (20:4 Δ5,8,11,14) of the linoleic acid series and especially docosahexaenoic acid (22:6 Δ4,7,10,13,16,19) of the linolenic acid series. The higher levels of 22:6 in brain, in comparison with other tissues, suggest a special function of the n-3 fatty acid family in nervous system. It has been recently found, for instance, that the electrical response of rod outer segments in the retina to illumination is affected by dietary induced changes of 22:6 n-3 levels in this tissue (Wheeler et al., 1970).

Keywords

Arachidonic Acid Essential Fatty Acid Brain Cortex Essential Fatty Acid Deficiency Free Arachidonic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • C. Galli
    • 1
  • G. Galli
    • 1
  • C. Spagnuolo
    • 2
  • E. Bosisio
    • 2
  • L. Tosi
    • 2
  • G. C. Folco
    • 2
  • D. Longiave
    • 2
  1. 1.Laboratory of Applied BiochemistryItaly
  2. 2.Institute of Pharmacology and PharmacognosyUniversity of MilanMilanItaly

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