Biosynthetic Pathways of Polyunsaturated Fatty Acids
The type and amount of any unsaturated fatty acid found in lipids must be regulated by integrated control mechanisms directed both towards unsaturated fatty acid and lipid biosynthesis. The types and amounts of unsaturated fatty acids produced must be determined both by the number of enzymes involved in this process and the substrate specificity of these enzymes. In addition those factors which influence enzyme activity must also regulate the rate at which unsaturated fatty acids are produced. The results presented below summarize the studies carried out in our laboratory in an attempt to further determine what regulates unsaturated fatty acid biosynthesis.
KeywordsUnsaturated Fatty Acid Liver Lipid Microsomal Protein Chain Elongation Octadecadienoic Acid
Unable to display preview. Download preview PDF.
- Gurr, M. I. (1974) in Biochemistry of Lipids (Goodwin, T. W., ed.) Vol. 4, pp. 181–236, University Park Press, Baltimore.Google Scholar
- Holman, R. T. (1964) Federation Proc. 23, 1062–1067.Google Scholar
- Klenk, E. (1965) in Advances in Lipid Research (Paoletti, R. & Kritchevsky, D. eds.) Vol. 3, pp. 1–23, Academic Press, London & New York.Google Scholar
- Mead, J. F. & Fulco, A. J. (1976) in The Unsaturated and Polyun saturated Fatty Acids in Health and Disease (Kugelmass, I. N. ed.) pp. 52–103, Charles C. Thomas, Springfield, Illinois.Google Scholar
- Sprecher, H. (1968a) Biochim. Biophys. Acta 152, 519–530.Google Scholar
- Sprecher, H. (1972) Federation Proc. 31, 1451–1457.Google Scholar