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The Biosynthesis of Prostaglandins and Thromboxanes by Nervous Tissue

  • L. S. Wolfe
  • J. Marion
  • K. Rostworowski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)

Abstract

Prostaglandins F and E2 are rapidly synthesized and released in vivo from various regions of the central nervous system and from autonomic nerves during stimulation or after trauma (Wolfe, 1975). They alter the effects of neurotransmitters at pre- and postsynaptic sites. PG’s appear in increased amounts in human CSF following epileptic seizures, trauma, infections and stroke (Wolfe & Mamer, 1975). Measurement of PG biosynthesis by cerebral cortex and other brain regions in vitro shows considerable biosynthetic capacity from endogenous precursors, Catabolic enzyme activities however are exceedingly low. A metabolically stable pool of arachidonic acid appears in brain tissue after animal death which saturates the brain fatty acid cyclo-oxygenase (Wolfe et al., 1976a; 1976c) localized in microsomal membrane elements (Baker, R. R. & Wolfe, L. S., unpublished results).

Keywords

Arachidonic Acid Cerebellar Tissue Postsynaptic Site Free Arachidonic Acid Stable Pool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bazan, N. G. (1971) J. Neurochem. 18, 1379–1385.PubMedCrossRefGoogle Scholar
  2. Cenedella, R. J., Galli, C. & Paoletti, R. (1975) Lipids 10, 5, 290–293.CrossRefGoogle Scholar
  3. Lunt, G. G. & Rowe, C. E. (1968) Biochim. Biophys. Acta 152, 681–693.PubMedGoogle Scholar
  4. MacDonald, G., Baker, R. R. & Thompson, W. (1975) J. Neurochem. 27, 655–661.Google Scholar
  5. Woelk, H. & Porcellati, G. (1973) Hoppe Seyler’s Z. Physiol. Chem. 354, 90–100.PubMedCrossRefGoogle Scholar
  6. Wolfe, L. S. (1975) in Advances in Neurochemistry, Vol. I (Agranoff, B. W. & Aprison, M. H., eds.) pp. 1–49. Plenum Publishing Corp., New York.Google Scholar
  7. Wolfe, L. S. & Mamer, O. A. (1975) Prostaglandins 9, 183–192.PubMedCrossRefGoogle Scholar
  8. Wolfe, L. S., Pappius, H. M. & Marion, J. (1976a) in Advances in Prostaglandin and Thromboxane Research, Vol. 1 (Samuelsson, B. & Paoletti, R., eds.) pp. 345–355. Raven Press, New York.Google Scholar
  9. Wolfe, L. S., Rostworowski, K. & Marion, J. (1976b) Biochem. Biophys. Res. Comm. 70, 907–913.PubMedCrossRefGoogle Scholar
  10. Wolfe, L. S., Rostworowski, K. & Pappius, H. M. (1976c) Can. J. Biochem. 54, 629–640.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • L. S. Wolfe
    • 1
  • J. Marion
    • 1
  • K. Rostworowski
    • 1
  1. 1.Montreal Neurological InstituteMcGill University MontrealQuebecCanada

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