The Biosynthesis of Prostaglandins and Thromboxanes by Nervous Tissue
Prostaglandins F2α and E2 are rapidly synthesized and released in vivo from various regions of the central nervous system and from autonomic nerves during stimulation or after trauma (Wolfe, 1975). They alter the effects of neurotransmitters at pre- and postsynaptic sites. PG’s appear in increased amounts in human CSF following epileptic seizures, trauma, infections and stroke (Wolfe & Mamer, 1975). Measurement of PG biosynthesis by cerebral cortex and other brain regions in vitro shows considerable biosynthetic capacity from endogenous precursors, Catabolic enzyme activities however are exceedingly low. A metabolically stable pool of arachidonic acid appears in brain tissue after animal death which saturates the brain fatty acid cyclo-oxygenase (Wolfe et al., 1976a; 1976c) localized in microsomal membrane elements (Baker, R. R. & Wolfe, L. S., unpublished results).
KeywordsArachidonic Acid Cerebellar Tissue Postsynaptic Site Free Arachidonic Acid Stable Pool
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