Metabolism and Role of Phosphatidylinositol in Acetylcholinestimulated Membrane Function
I should like to discuss some of the work from this laboratory on the nature and function of stimulus-induced changes in phosphatidylinositol metabolism. Such changes have long been known to occur in many types of cells in response to stimulation by some neurotransmitters, hormones, and various other agents. In the early work, the changes were characterized as an increased turnover of the hydrophilic part of the phosphatidylinositol moleculephosphate and inositol — without a concomitant increase in the turnover of the hydrophobic, diglyceride part of the molecule. Tissues which show such a response include, among others, neural tissue and some exocrine and endocrine glands.
KeywordsRough Endoplasmic Reticulum Phosphatidic Acid Exocrine Pancreas Salt Gland Zymogen Granule
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- Harris D. W. & Hokin-Neaverson M. (1977) Federation Proc. (In press)Google Scholar
- Hokin L. E. & Hokin M. R. (1963) Federation Proc. 22, 8–18Google Scholar
- Hokin M. R. & Hokin L. E. (1964) in Metabolism and Significance of Lipids. (Dawson R.M.C. & Rhodes D.N., eds.) pp. 423–434, John Wiley, London.Google Scholar
- Hokin M. R. (1965) in Funktionelle und morphologische Organisation der Zelle; Sekretion und Excretion. (Wohlfarth-Bottermann, K.E., ed) pp. 283–288, Springer-Verlag, Berlin, Heidelberg and New York.Google Scholar
- Hokin M. R. (1967) Neurosci. Res. Prog. Bull. 5, 32–36Google Scholar
- Hokin M. R. (1974) in Secretory Mechanisms of Exocrine Glands. (Thorn N.A. & Petersen O.N., eds.) pp. 101–112, Munksgaard, Copenhagen.Google Scholar
- Komnick H. & Kniprath E. (1970) Cytobiologie 1, 228–247Google Scholar
- Michell R. H. & Lapetina E. G. (1972) Nature 240, 258–260Google Scholar
- Petzold G. L. & Agranoff B. W. (1965) Federation Proc. 24, 426Google Scholar
- Raetz C. R. H., Hirschberg C. B., Dowhan W., Wickner W. T. & Kennedy E. P. (1972) J. Biol, Chem. 247, 2245–2247Google Scholar
- Schacht J. & Agranoff B. W. (1974b) in Neurochemistry of Cholinergic Receptors. (de Robertis, E. & Schacht, J., eds.) pp. 121–129, Raven Press, New York.Google Scholar