Metabolism of Phosphatidic Acid and Phosphatidylinositol in Relation to Transmitter Release from Synaptosomes

  • J. N. Hawthorne
  • M. R. Pickard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


Phosphatidylinositol accounts for about one-twentieth of the total phospholipid fraction of nervous tissue. Phosphatidic acid, the precursor of phosphatidylinositol and a key intermediate in lipid metabolism, occurs in smaller amounts. The possible involvement of these phospholipids in synaptic transmission was first suggested by the work of Hokin & Hokin (1954) showing that acetylcholine increased the incorporation of labelled phosphate into lipids of brain slices. Phosphatidic acid and phosphatidylinositol were the compounds chiefly affected. Diphosphoinositide and triphosphoinositide, the phosphorylated derivatives of phosphatidylinositol, did not respond to acetylcholine.


Electrical Stimulation Phosphatidic Acid Transmitter Release Specific Radioactivity Synaptosomal Membrane 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. N. Hawthorne
    • 1
  • M. R. Pickard
    • 1
  1. 1.Department of BiochemistryUniversity Hospital and Medical SchoolNottinghamEngland, UK

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