Metabolism of Phosphatidic Acid and Phosphatidylinositol in Relation to Transmitter Release from Synaptosomes
Phosphatidylinositol accounts for about one-twentieth of the total phospholipid fraction of nervous tissue. Phosphatidic acid, the precursor of phosphatidylinositol and a key intermediate in lipid metabolism, occurs in smaller amounts. The possible involvement of these phospholipids in synaptic transmission was first suggested by the work of Hokin & Hokin (1954) showing that acetylcholine increased the incorporation of labelled phosphate into lipids of brain slices. Phosphatidic acid and phosphatidylinositol were the compounds chiefly affected. Diphosphoinositide and triphosphoinositide, the phosphorylated derivatives of phosphatidylinositol, did not respond to acetylcholine.
KeywordsElectrical Stimulation Phosphatidic Acid Transmitter Release Specific Radioactivity Synaptosomal Membrane
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- Hokin, L.E. (1969) in Structure and Function of Nervous Tissue, vol. III (Bourne, G.H., ed.) pp.161–184. Academic Press, New YorkGoogle Scholar