Metabolism of Phosphatidylcholine in the Central Nervous System

  • E. F. Soto
  • R. Najle
  • I. F. de Raveglia
  • J. M. Pasquini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


In the present paper we describe the results of our studies on the biosynthesis and turnover of phosphatidyl choline (PC) in rat brain. We will discuss the apparent lack of phospholipid transport mechanisms in cell membranes of the CNS and will show that all brain subcellular fractions seem to have a certain degree of independence for the synthesis of this phospholipid. The presence of rapid and slow turnover pools for PC will be described and possible explanations for these findings will be presented.


Nerve Ending Subcellular Fraction Phosphatidyl Choline Specific Radioactivity Intracranial Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arvidson, G.A.E. (1968a) Europ. J. Biochem. 4, 478–486.PubMedCrossRefGoogle Scholar
  2. Arvidson, G.A.E. (1968b) Europ. J. Biochem. 5, 415–421.PubMedCrossRefGoogle Scholar
  3. Benjamins, J.A. & McKhann, G.M. (1973) J. Neurochem. 20, 1121–1129.PubMedCrossRefGoogle Scholar
  4. Cotman, C.W. & Matthews, D.A. (1971) Biochim. Biophys. Acta 249, 380–394.PubMedCrossRefGoogle Scholar
  5. De Robertis, E.; Pellegrino de Iraldi, A.; Rodriguez de Lorez Arnaiz, G. & Salganicoff, L. (1962) J. Neurochem. 9, 23–35.PubMedCrossRefGoogle Scholar
  6. Freysz, L.; Bieth, R. & Mandel, P. (1969) J. Neurochem. 16, 1417–1424.PubMedCrossRefGoogle Scholar
  7. Folch, J.; Lees, M. & Sloane Stanley, G.H. (1957) J. Biol. Chem. 226, 497–509.PubMedGoogle Scholar
  8. Gómez, C.J.; Pasquini, J.M.; Soto, E.F. & De Robertis, E. (1970) J. Neurochem. 17, 1485–1492.PubMedCrossRefGoogle Scholar
  9. Herschkowitz, N.; McKhann, G.M. & Shooter, E.M. (1967) J. Neurochem. 17, 1485–1492.Google Scholar
  10. Horrocks, L.A.; Toews, A.D.; Thompson, D.K. & Chin, J.Y. (1975), In Function and Metabolism of phospholipids in CNS and PNS (G. Porcellati, ed.) pp 1–18, Plenum Press, London.Google Scholar
  11. Jungalwala, F. & Dawson, R.M.C. (1970) Biochem. J. 117, 481–490.PubMedGoogle Scholar
  12. Jungalwala, F. (1974) Brain Res. 78, 99–108.PubMedCrossRefGoogle Scholar
  13. Kanoh, H. (1969) Biochim. Biophys. Acta 176, 756–763.PubMedGoogle Scholar
  14. McCaman, R.E. & Cook, K. (1966) J. Biol. Chem. 241, 3390–3397.PubMedGoogle Scholar
  15. McMurray, W.C. & Dawson, R.M.C. (1969) Biochem. J. 126, 805–821.Google Scholar
  16. Miller, E.K. & Dawson, R.M.C. (1972) Biochem. J. 126, 823–835.PubMedGoogle Scholar
  17. O’Brien, J.F. & Geison, R.L. (1974) J. Lipid Res. 15, 44–49.PubMedGoogle Scholar
  18. Parkes, J.G. & Thompson, W. (1973) J. Biol. Chem. 248, 6655–6662.PubMedGoogle Scholar
  19. Parkes, J.G. & Thompson, W. (1975) Canad. J. Biochem. 53, 698–705.CrossRefGoogle Scholar
  20. Pasquini, J.M.; Gómez, C.J.; Najle, R. & Soto, E.F. (1975) J. Neurochem. 24, 439–443.PubMedCrossRefGoogle Scholar
  21. Pasquini, J.M.; Krawiec, L. & Soto, E.F. (1973) J. Neurochem. 21, 647–653.PubMedCrossRefGoogle Scholar
  22. Pleasure, D.E. & Prockop, D.J. (1972) J. Neurochem. 19, 283–295.PubMedCrossRefGoogle Scholar
  23. Seminario, L.; Soto, E.F. & Cohan, T. (1965) J. Chromatog. 17, 513–519.CrossRefGoogle Scholar
  24. Soto, E.F.; Pasquini, J.M. & Krawiec, L. (1972) Archs. Biochem. Biophys. 150, 362–370.CrossRefGoogle Scholar
  25. Van Golde, L.M.G.; Scherphof, G.L. & Van Deenen, L.L.M. (1969) Biochim. Biophys. Acta 176, 635–637.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • E. F. Soto
    • 1
  • R. Najle
    • 1
  • I. F. de Raveglia
    • 1
  • J. M. Pasquini
    • 1
  1. 1.Departamento de Química BiológicaFacultad de Farmacia y BioquímicaBuenos AiresArgentina

Personalised recommendations