Transformations of the Polyunsaturated Fatty Acids in the Brain

  • J. F. Mead
  • G. A. Dhopeshwarkar
  • M. Gan Elepano
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


A great deal of research from several laboratories, including ours, has given a picture, incomplete, to be sure, of the many reactions that combine to determine the composition of the brain lipids. These are outlined in Fig, 1, which provides an overview of the sources and metabolic transformations of the fatty acids that contribute their properties to the major phosphoglycerides and sphingolipids that form the chief structural units of the membranes that are involved in most of the properties of the brain.


Saturated Fatty Acid Neutral Lipid Substrate Fatty Acid Endogenous Fatty Acid Exogenous Fatty Acid 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. F. Mead
    • 1
  • G. A. Dhopeshwarkar
    • 1
  • M. Gan Elepano
    • 1
  1. 1.Laboratory of Nuclear Medicine and Radiation Biology Department of Biological Chemistry, School of MedicineUniversity of CaliforniaLos AngelesUSA

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