The Role of Dolichol in Protein Glycosylation

  • L. F. Leloir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


Lipid intermediates were first detected in studies on the biosynthesis of lipopolysaccharide and of proteoglycan in bacteria. These intermediates turned out to be sugar derivatives of polyisoprenoid alcohols. A series of these compounds has been isolated from various organisms.


Protein Glycosylation Sugar Nucleotide Trans Double Bond Neuraminic Acid High Mannose Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. The selection of references is strongly biased in favour of our laboratory and I apologize for this. Other workers whose names do not appear have also made important contributions.Google Scholar
  2. Adamany A. M. & Spiro R. G. (1975) J. Biol. Chem. 250, 2842–2854PubMedGoogle Scholar
  3. Babczinki P & Tanner W. (1973) Biochem. Biophys. Res. Commun. 54, 1119–1124CrossRefGoogle Scholar
  4. Behrens N. H. & Leloir L. F. (1970) Proc. Natl. Acad. Sci. U.S.A. 66, 153–159PubMedCrossRefGoogle Scholar
  5. Behrens N. H., Parodi A. J. & Leloir L. F. (1971a) Proc. Natl. Acad. Sci. U.S.A. 68, 2857–2860PubMedCrossRefGoogle Scholar
  6. Behrens N. H., Parodi A. J., Leloir L. F. & Krisman C. R. (1971b) Arch. Biochem. Biophys. 143, 375–383PubMedCrossRefGoogle Scholar
  7. Behrens N. H., Carminatti H., Staneloni R., Leloir L. F. & Cantarella A. I. (1973) Proc. Natl. Acad. Sci. U.S.A. 70, 3390–3394PubMedCrossRefGoogle Scholar
  8. Behrens N. H. (1974) Biology and Chemistry of Eucaryotic Cell Surfaces (Lee, E.Y.C. and Smith E.E. eds.), Vol.7, pp. 159–178, Academic Press, New York.Google Scholar
  9. Brett C. & Leloir L. F. (1976) Biochem. J. (in press)Google Scholar
  10. Gottschalk A., ed. (1972) Glycoproteins, Elsevier, AmsterdamGoogle Scholar
  11. Hemming F. W. (1974) in Biochemistry of Lipids (Goodwin T. W., ed.), Vol. 4 pp. 39–97, Butterworths and University Park Press, London and BaltimoreGoogle Scholar
  12. Hsu A. F., Baynes J. W. & Heath E. C. (1974) Proc. Natl. Acad. Sci. U.S.A. 71, 2391–2395PubMedCrossRefGoogle Scholar
  13. Kornfeld R. & Kornfeld S. (1976) Annu. Rev. Biochem. 45, 217–237PubMedCrossRefGoogle Scholar
  14. Lehle L., Fartaczek F., Tanner W. & Kauss H. (1976) Arch. Biochem. Biophys. 175, 419–426PubMedCrossRefGoogle Scholar
  15. Leloir L. F., Staneloni R. J., Carminatti H. & Behrens N. H. (1973) Biochem. Biophys. Res. Commun. 52, 1285–1292PubMedCrossRefGoogle Scholar
  16. Lennarz W. J. (1975) Science 188, 986–991PubMedCrossRefGoogle Scholar
  17. Levy J. A., Carminatti H., Cantarella A. I., Behrens N. H., Leloir L. F. & Tabora E. (1974) Biochem. Biophys. Res. Commun. 60, 118–125PubMedCrossRefGoogle Scholar
  18. Lucas J. J., Waechter C. J. & Lennarz W. J. (1975) J. Biol. Chem. 250, 1992–2002PubMedGoogle Scholar
  19. Marshall R. D. & Neuberger A. (1970) in Advances of Carbohydrate Chemistry and Biochemistry (Stuart Tipson, R. and Horton, D., eds), Vol. 25, pp. 407–478. Academic PressCrossRefGoogle Scholar
  20. Montreuil J. (1975) Pure and Applied Chem. 42, 431–477CrossRefGoogle Scholar
  21. Parodi A. J., Behrens N. H., Leloir L. F. & Carminatti H. (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 3268–3272.PubMedCrossRefGoogle Scholar
  22. Parodi A. J., Staneloni R., Cantarella A. I., Leloir L. F., Behrens N. H., Carminatti H. & Levy J. A. (1973) Carbohyd. Res. 26, 393–400CrossRefGoogle Scholar
  23. Parodi A. J. & Leloir L. F. (1975) Trends in Biochemical Sciences 1, 58–59Google Scholar
  24. Pont-Lezica R., Brett C., Romero P. & Dankert M. (1975) Biochim. Biophys. Res. Commun. 66, 980–987CrossRefGoogle Scholar
  25. Quesada Allue L. A., Marechal L. R. & Belocopitow E. (1976) Febs Lett. 67, 243–247PubMedCrossRefGoogle Scholar
  26. Spiro R. G. (1973) in Advances in Protein Chemistry (Anfinsen C.B., Edsall J.T. and Richards F.M. eds) Vol. 27, pp. 349–467, Academic Press, New YorkGoogle Scholar
  27. Waechter C. J. & Lennarz W. J. (1976) Annu. Rev. Biochem. 45, 95–112PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • L. F. Leloir
    • 1
  1. 1.Instituto de Investigaciones Bioquímicas “Fundación Campomar” y Facultad de Ciencias Exactas y NaturalesBuenos AiresArgentina

Personalised recommendations