The Role of Dolichol in Protein Glycosylation
Lipid intermediates were first detected in studies on the biosynthesis of lipopolysaccharide and of proteoglycan in bacteria. These intermediates turned out to be sugar derivatives of polyisoprenoid alcohols. A series of these compounds has been isolated from various organisms.
KeywordsProtein Glycosylation Sugar Nucleotide Trans Double Bond Neuraminic Acid High Mannose Type
Unable to display preview. Download preview PDF.
- The selection of references is strongly biased in favour of our laboratory and I apologize for this. Other workers whose names do not appear have also made important contributions.Google Scholar
- Behrens N. H. (1974) Biology and Chemistry of Eucaryotic Cell Surfaces (Lee, E.Y.C. and Smith E.E. eds.), Vol.7, pp. 159–178, Academic Press, New York.Google Scholar
- Brett C. & Leloir L. F. (1976) Biochem. J. (in press)Google Scholar
- Gottschalk A., ed. (1972) Glycoproteins, Elsevier, AmsterdamGoogle Scholar
- Hemming F. W. (1974) in Biochemistry of Lipids (Goodwin T. W., ed.), Vol. 4 pp. 39–97, Butterworths and University Park Press, London and BaltimoreGoogle Scholar
- Parodi A. J. & Leloir L. F. (1975) Trends in Biochemical Sciences 1, 58–59Google Scholar
- Spiro R. G. (1973) in Advances in Protein Chemistry (Anfinsen C.B., Edsall J.T. and Richards F.M. eds) Vol. 27, pp. 349–467, Academic Press, New YorkGoogle Scholar