Advertisement

Effects of Brain Gangliosides on Reinnervation of Fast-Twitch Rat Skeletal Muscle

  • B. Ceccarelli
  • F. Aporti
  • M. Finesso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)

Abstract

We have recently produced evidence showing that treatment with gangliosides substantially increases the rate and degree of functional recovery that follows the process of regeneration of nerve fibers (Ceccarelli et al., 1976). Our previous results were obtained in two different experimental models involving the regeneration of peripheral sympathetic cholinergic and adrenergic nerve fibers (see also Ceccarelli et al., 1971; 1972). The results of these experiments clearly indicated that both in a cholinergic type (preganglionic) and in an adrenergic type (postganglionic) of anastomosis prolonged treatment with a mixture of brain cortex gangliosides induced an increased rate and degree of functional recovery, as measured by electrophysiological means. This might be explained by a more efficient reinnervation on the effector organs(superior cervical ganglion and smooth muscle of nictitating membrane). Although it is difficult at the present to account for this observation we thought that it might be useful to investigate the pharmacological effect of gangliosides in the physiological characteristics of reinnervation also of mammalian skeletal muscle fibers. We report here an account of our preliminar experiments, using the fast-twitch extensor digitorum longus (hereafter called EDL) muscle and its nerve supply.

Keywords

Functional Recovery Untreated Animal Superior Cervical Ganglion Nictitate Membrane Brain Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albuquerque E.N. & McIssac R.J. (1970) Exp. Neurol. 26, 183–202PubMedCrossRefGoogle Scholar
  2. Axelsson J. & Thesleff S. (1959) J. Physiol. 147, 178PubMedGoogle Scholar
  3. Ceccarelli B., Clementi F. & Mantegazza P. (1971) J. Physiol. 216, 87–98PubMedGoogle Scholar
  4. Ceccarelli B., Clementi F. & Mantegazza P. (1972) J. Physiol. 220, 211–227PubMedGoogle Scholar
  5. Ceccarelli B., Aporti F. & Finesso M. (1976) In ganglioside function: biochemical and pharmacological implications, pp. 275–293. Plenum Press, New York and London.Google Scholar
  6. Jones R. & Vrbova G. (1974) J. Physiol. 236, 517–538PubMedGoogle Scholar
  7. Miledi R. (1960) J. Physiol. 151, 1–23PubMedGoogle Scholar
  8. Tonge D.A. (1974) J. Physiol. 241, 141–153PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. Ceccarelli
    • 1
  • F. Aporti
    • 2
  • M. Finesso
    • 2
  1. 1.Department of Pharmacology C.N.R. Center of CytopharmacologyUniversity of MilanoMilanoItaly
  2. 2.Fidia Res. LaboratoryAbano TermeItaly

Personalised recommendations