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The Biosynthesis of Brain Gangliosides — Evidence for a “Transient Pool” and an “End Product Pool” of Gangliosides

  • H. J. Maccioni
  • C. Landa
  • A. Arce
  • R. Caputto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)

Abstract

Incubation of sugar nucleotides with brain membranes in which endogenous, incomplete gangliosides are glycosylated, and addition of sugars to exogenous acceptors indicated the same pathway of synthesis of gangliosides (for a review, see Caputto et al. 1974; 1976). An exception was the pathway of completion of GDlb, for which a different route was worked out using endogenous (Arce et al., 1971) or exogenous acceptors (Cumar et al., 1971; 1972). The pathway of synthesis found for GTlb (Arce et al., 1971) was recently confirmed by using exogenous acceptors (Mestrallet et al., 1974).

Keywords

Microsomal Fraction Optic Tectum Carbohydrate Chain Total Homogenate Neuraminidase Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • H. J. Maccioni
    • 1
  • C. Landa
    • 1
  • A. Arce
    • 1
  • R. Caputto
    • 1
  1. 1.Departamento de Química Biológica Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina

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