The Biosynthesis of Brain Gangliosides — Evidence for a “Transient Pool” and an “End Product Pool” of Gangliosides

  • H. J. Maccioni
  • C. Landa
  • A. Arce
  • R. Caputto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 83)


Incubation of sugar nucleotides with brain membranes in which endogenous, incomplete gangliosides are glycosylated, and addition of sugars to exogenous acceptors indicated the same pathway of synthesis of gangliosides (for a review, see Caputto et al. 1974; 1976). An exception was the pathway of completion of GDlb, for which a different route was worked out using endogenous (Arce et al., 1971) or exogenous acceptors (Cumar et al., 1971; 1972). The pathway of synthesis found for GTlb (Arce et al., 1971) was recently confirmed by using exogenous acceptors (Mestrallet et al., 1974).


Microsomal Fraction Optic Tectum Carbohydrate Chain Total Homogenate Neuraminidase Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arce, A., Maccioni, H. J. & Caputto, R. (1966) Arch. Biochem. Biophys., 116, 52.PubMedCrossRefGoogle Scholar
  2. Arce, A., Maccioni, H. J. & Caputto, R. (1971) Biochem. J., 121, 483.PubMedGoogle Scholar
  3. Caputto, R., Maccioni, H. J. & Arce, A. (1974) Mol. Cell. Biochem., 4, 97.PubMedCrossRefGoogle Scholar
  4. Caputto, R., Maccioni, H. J., Arce, A. & Cumar, F. A. (1976) Adv. Exptl. Med. Biol., 71, 27.Google Scholar
  5. Cumar, F. A., Fishman, P. H. & Brady, R. O. (1971) J. Biol. Chem., 246, 5075.PubMedGoogle Scholar
  6. Cumar, F. A., Tallman, J. F. & Brady, R. O. (1972) J. Biol. Chem., 247, 2322.PubMedGoogle Scholar
  7. Curtino, J. A., & Caputto, R. (1972) Lipids, 8, 525.CrossRefGoogle Scholar
  8. Curtino, J. A., & Caputto, R. (1974) Biochem. Biophys. Res. Commun., 56, 142.PubMedCrossRefGoogle Scholar
  9. Den, H., Kaufman, B., McGuire, E. J. & Roseman, S. (1975) J. Biol. Chem., 250, 739.PubMedGoogle Scholar
  10. di Cesare, J. L., & Dain, J. A. (1972) J. Neurochem., 19, 403.CrossRefGoogle Scholar
  11. Eichberg, J., Whittaker, V. P. & Dawson, R. M. C. (1964) Biochem. J. 92, 91.PubMedGoogle Scholar
  12. Fishman, P. H. (1974) Chem. Phys. Lipids, 13, 305.PubMedCrossRefGoogle Scholar
  13. Forman, D. S. & Ledeen, R. W. (1972) Science, N. Y., 177, 630.CrossRefGoogle Scholar
  14. Gurd, J. W., Jones, L. R., Mahler, H. R. & Moore, W. J. (1974) J. Neurochem., 22, 281.PubMedCrossRefGoogle Scholar
  15. Holm, M. (1972) J. Neurochem., 19, 623.PubMedCrossRefGoogle Scholar
  16. James, A. C. K., Bray, J. J., Morgan, I. G. & Austin, L. (1970) Biochem. J., 117, 767.PubMedGoogle Scholar
  17. Kaufman, B. Basu, S. & Roseman, S. (1966) Proc. 3rd. int. Sypm. Cerebral Sphingolipidosis, p. 193. Ed. by Aronson, S. M. & Volk, B. N. New York, Pergamon Press Inc.Google Scholar
  18. Keenan, T. W., Morre, D. J. & Basu, S. (1974) J. Biol. Chem. 249, 310.PubMedGoogle Scholar
  19. Ledeen, R. W., Skrivanek, J. A., Tirri, L. J., Margolis, R. K. & Margolis, R. U. (1976) Adv. Exptl. Med. Biol., 71, 83.Google Scholar
  20. Maccioni, H. J., Arce, A. & Caputto, R. (1971) Bichem. J., 125, 1131.Google Scholar
  21. Maccioni, H. J., Arce, A. & Caputto, R. (1972) in Biochemistry of the Glycoside linkage (R. Piras & H. Pontis, eds.) p. 413. Academic Press, New York and London.Google Scholar
  22. Maccioni, H. J., Arce, A., Landa, C. & Caputto, R. (1974) Biochem. J., 138, 291.PubMedGoogle Scholar
  23. Mestrallet, M. G., Cumar, F. A. & Caputto, R. (1974) Biochem. Biophys. Res. Commun., 59, 1.PubMedCrossRefGoogle Scholar
  24. Morgan, I. G., Wolfe, L. S., Mandel, P. & Gombos, G. (1971) Biochim. Biophys. Acta, 241, 737.PubMedCrossRefGoogle Scholar
  25. Neskovic, N. M., Sarlive, L. L. & Mandel, P. (1973) J. Neurochem. 20, 1419.PubMedCrossRefGoogle Scholar
  26. Raghupathy, E., Ko, G. K W. & Peterson, N. A. (1972) Biochim. Biophys. Acta, 286, 339.PubMedCrossRefGoogle Scholar
  27. Roseman, S. (1970) Chem. Phys. Lipids,. 5, 270.PubMedCrossRefGoogle Scholar
  28. Rosner, H., Wiegandt, H. & Rahmann, H. (1973) J. Neurochem., 21, 655.PubMedCrossRefGoogle Scholar
  29. Rosner, H., (1975) Brain Research, 97, 107.PubMedCrossRefGoogle Scholar
  30. Rothfield, L., Romeo, D & Hincley, A. (1972) Fed. Proc., 31, 12.PubMedGoogle Scholar
  31. Seijo, L. & Rodriguez De Lores Arnaiz, G. (1970) Biochim. Biophys. Acta, 211, 595.PubMedCrossRefGoogle Scholar
  32. Shah, S. N. (1973) Arch-Bichem. Biophys., 159, 143.CrossRefGoogle Scholar
  33. Sjostrand, J., Frizell, M. & Hasselgren, P. O. (1970) J. Neurochem. 17, 1563.PubMedCrossRefGoogle Scholar
  34. Whittaker, V. P., Michaelson, I. A. & Kirkland, J. A. (1964) Biochem. J., 90, 293.PubMedGoogle Scholar
  35. Whittaker, V. P., (1969) Handbook of Neurochemistry (Lajtha A., ed.) Vol. II, p. 327.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • H. J. Maccioni
    • 1
  • C. Landa
    • 1
  • A. Arce
    • 1
  • R. Caputto
    • 1
  1. 1.Departamento de Química Biológica Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina

Personalised recommendations