The Lipid Composition and Ca Transport Function of Sarcoplasmic Reticulum(SR) Membranes during Development in Vivo and in Vitro
Lipids play an essential role in the structure and function of biological membranes. The concept that the lipid enviroment influences the activity of membrane bound enzymes is now generally accepted. The sarcoplasmic reticulum(SR) of skeletal muscle is an intracellular membranous system with an important physiological role in contraction and relaxation (Hasselbach, 1964; Martonosi, 1971). The Ca2+ transport and (Ca2+ + Mg2+)-ATPase activities which exhibit isolated SR preparations have been shown to be dependent on membrane phospholipids (Martonosi, 1968). An involvement of the fatty acid component of phospholipids in the functioning of the Ca2+ pump has also been suggested (Seiler et al., 1970; Seiler & Hasselbach, 1971). With the purpose of further exploring the relationships existing between lipids and other components of sarcoplasmic reticulum and its Ca transport function, changes in biochemical composition were correlated with variations in Ca2+ uptake during development of skeletal muscle in vivo and in vitro.
KeywordsFatty Acid Composition Sarcoplasmic Reticulum Short Chain Fatty Acid Skeletal Muscle Cell Fatty Acid Component
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