Interactions with Phospholipid Monolayers of Lipids and Water-Soluble Compounds That Induce Membrane Fusion
Hen erythrocytes fuse into multinucleated cells on incubation under defined conditions “in vitro” with a variety of chemical agents. These include various unsaturated and low-melting fat-solu ble substance (Ahkong et al., 1973; 1974), dimethyl sulphoxide, glycerol and other polyols, and poly(ethyleneglycol)(Ahkong et al., 1975a; 1975b). The present communication reports some effects of these compounds on phospholipid monolayers that may be related to the molecular mechanism of chemically-induced membrane fusion.
KeywordsLipid Bilayer Surface Potential Membrane Fusion Dimethyl Sulphoxide Polar Head Group
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