Approaches to the Biochemistry of Regeneration in the Central Nervous System
Our laboratory has a long-standing interest in the biochemical basis of central nervous system plasticity. We have come to recognize that many of the ultimate answers we seek are imbedded in the more general question of the biochemical basis of neural development. That is, until we learn how cells recognize and mark one another during development, we will probably not understand fully how neurons connect with one another. Present experimental approaches to the general problem of cell recognition in the nervous system, as well as in a number of other eukaryotic preparations, range from the whole animal model—a biochemical extension of classical embryology—to reductionist models. An example of the latter is the reaggregation of dissociated cells or their selective adhesion to other cells or to cell membranes. Lipid biochemists have been drawn to the area of cell recognition since it has become increasingly apparent that some cell surface determinants, at least at the immunological level, may be lipid in nature.
KeywordsOptic Nerve Retinal Ganglion Cell Cholesterol Ester Ganglion Cell Layer Optic Nerve Crush
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