Fetal and Placental O2 Consumption and the Uptake of Different Metabolites in the Ruminant and Horse during Late Gestation

  • Marian Silver
  • R. S. Comline
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

The use of conscious pregnant animals with indwelling catheters in both fetal and maternal circulations has enabled a variety of measurements to be made on a long-term basis. In the sheep, changes in uterine and umbilical blood flows have been followed during the latter part of gestation (for references see Comline & Silver 1974) and such measurements coupled with analyses of arterio-venous differences in oxygen and other metabolites allow the calculation of fetal and utero-placental oxygen consumption and metabolite uptake (Battaglia & Meschia 1973). The picture which has emerged is that the rates of both uterine and umbilical blood flow keep pace with the growth of the fetus so that its oxygen uptake per unit weight remains relatively constant. However, in their calculations of the energy balance of the sheep fetus Battaglia & Meschia (1973) noticed that the amount of oxygen used by the fetus was greater than could be explained by the uptake and metabolism of glucose, amino acids and other possible metabolic fuels; at least 20–25% of the total oxygen consumption remained unaccounted for.

Keywords

Catheter Urea Fructose Butyrate Antipyrine 

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References

  1. Battaglia, P. C. & Meschia, G. (1973) in Foetal & Neonatal Physiology pp. 382–397. Eds. R. S. Comline, K. W. Cross, G. S. Dawes, & P. W. Nathanielsz. Cambridge University Press.Google Scholar
  2. Comline, R. S. & Silver, M. (1974) in Recent Advances in Physiology pp. 406–454. Ed. R. J. Linden. Churchill, London.Google Scholar
  3. Comline, R. S. & Silver, M. (1975a) J. Physiol. Lond. 245, 75–76P.Google Scholar
  4. Comline, R. S. & Silver, M. (1975b) J. Reprod. Pert. Suppl. 23 in press.Google Scholar
  5. Comline, R. S., Hall, L. W., Lavelle, R. B., Nathanielsz, P. W. & Silver, M. (1974) J. Endocr. 63, 451–472.PubMedCrossRefGoogle Scholar
  6. Crenshaw, C., Huckabee, W. E., Curet, L. B., Mann, L. & Barron, D. H. (1968) Q. J. exp. Physiol. 53, 65–75.Google Scholar
  7. Huckabee, W. E., Metcalfe, J., Prystowsky, H. & Barron, D. H. (1961) Am. J. Physiol. 200, 274–278.PubMedGoogle Scholar
  8. Morris, P. H., Boyd, R. D. H., Makowski, E. L., Meschia, G. & Battaglia, P. C. (1974) Proc. Soc. exp. Biol. Med. 145, 879–883.Google Scholar
  9. Setchell, B. P., Bassett, J. M., Hinks, N. T. & Graham, N. M. (1972) Q. J. exp. Physiol. 57, 257–266.Google Scholar
  10. Silver, M. & Comline, R. S. (1975) J. Reprod. Pert. Suppl. 23 in press.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Marian Silver
    • 1
  • R. S. Comline
    • 1
  1. 1.Physiological LaboratoryUniversity of CambridgeCambridgeUK

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