Development and Adaptation of Heart Mitochondrial Respiratory Chain Function in Fetus and in Newborn
The ability of mitochondria to undergo alterations in response to changes in oxygen availability is suggested by the data from animals studied at high altitude (1,2). During the transition from intrauterine to extrauterine life, the animal experiences a marked change in oxygen environment which might affect mitochondrial function. In order to investigate the roles of development and adaptation, freshly isolated cardiac mitochondria from lambs and puppies were studied. The development of mitochondrial respiratory function was examined in fetal lambs. The changes in respiratory capacity, cytochrome concentration, and calcium transport subsequent to the increase in oxygen environment following birth were determined in newborn lambs and puppies.
KeywordsCalcium Transport Heart Mitochondrion Adult Level Arterial Oxygen Tension Respiratory Capacity
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