Tissue PO2, VO2, Venous PO2 and Perfusion Pressure in Resting Dog Gracilis Muscle Perfused at Constant Flow
Verzar (14), who studied resting cat skeletal muscle in vivo, was the first to report that oxygen consumption (V̇o2) depended on blood flow. A dependent relationship has since been found in blood perfused skeletal muscle preparations of the cat (15,18), and rat (4). However, Nakamura (7) could find no dependency in cat skeletal muscle except at very low flow rates. In dog skeletal muscle Rein and Schneider (9) and Pappenheimer (8) found that V̇o2 was dependent on blood flow in the normal range (4–10 ml/100g tissue/ min.). On the other hand Stainsby and Otis (12) reported an independent V̇o2-flow relationship when perfusion pressure was varied in dog skeletal muscle except at very low flow rates (1–2 ml/100g/min.). In a recent study by Duran and Renkin (2) 25 of 35 dog gracilis muscle preparations showed an independent relationship, and one converted spontaneously from a dependent to an independent relationship.
KeywordsBlood Flow Skeletal Muscle Perfusion Pressure Independent Relationship Autoregulatory Response
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