Tissue PO2, VO2, Venous PO2 and Perfusion Pressure in Resting Dog Gracilis Muscle Perfused at Constant Flow

  • W. J. Whalen
  • D. Buerk
  • C. Thuning
  • B. E. KanoyJr.
  • W. N. Duran
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Verzar (14), who studied resting cat skeletal muscle in vivo, was the first to report that oxygen consumption (V̇o2) depended on blood flow. A dependent relationship has since been found in blood perfused skeletal muscle preparations of the cat (15,18), and rat (4). However, Nakamura (7) could find no dependency in cat skeletal muscle except at very low flow rates. In dog skeletal muscle Rein and Schneider (9) and Pappenheimer (8) found that V̇o2 was dependent on blood flow in the normal range (4–10 ml/100g tissue/ min.). On the other hand Stainsby and Otis (12) reported an independent V̇o2-flow relationship when perfusion pressure was varied in dog skeletal muscle except at very low flow rates (1–2 ml/100g/min.). In a recent study by Duran and Renkin (2) 25 of 35 dog gracilis muscle preparations showed an independent relationship, and one converted spontaneously from a dependent to an independent relationship.


Blood Flow Skeletal Muscle Perfusion Pressure Independent Relationship Autoregulatory Response 
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  1. 1.
    Coburn, R.F. and L.B. Mayers. Myoglobin O2 tension determined from measurements of carboxymyoglobin in skeletal muscle. Am. J. Physiol. 220: 66–74, 1971.PubMedGoogle Scholar
  2. 2.
    Duran, W.N. and E.M. Renkin. Oxygen consumption and blood flow in resting mammalian skeletal muscle. Am. J. Physiol. 226: 173–177, 1974.PubMedGoogle Scholar
  3. 3.
    Granger, H.J., A.H. Goodman and D.N. Granger. Intrinsic metabolism regulation of blood flow, O2 extraction and tissue O2 delivery in dog skeletal muscle. In: Oxygen Transport to Tissue, ed. by H.I. Bicher and D.F. Bruley, 37A: 451–456, 1973.Google Scholar
  4. 4.
    Honig, C.R., J.L. Frierson and C.N. Nelson. O2 transport and V̇o2 in resting muscle: sig ificance for tissue-capillary exchange. Am. J. Physiol. 220: 357–363, 1971.Google Scholar
  5. 5.
    Jobsis, F.F. Basic processes in cellular respiration. In: Handbook of Physiology. Respiration. Washington, D.C.: Am. Physiol. Soc, 1964, sect, 3, vol. 1, chapt. 2, p. 63–124.Google Scholar
  6. 6.
    Kunze, K. Significance of oxygen pressure field measurements in human muscle, with special remarks on Po2 micro-needle electrodes. Progr. Resp. Res. 3: 153–157.Google Scholar
  7. 7.
    Nakamura, H. The oxygen use of muscle and the effect of sympathetic nerves on it. J. Physiol., London 55: 100–110, 1921.Google Scholar
  8. 8.
    Pappenheimer, J.R. Bloodflow, arterial oxygen saturation and oxygen consumption in the isolated perfused hind limb of the dog. J. Physiol. Iondon 99: 283–303, 1941.Google Scholar
  9. 9.
    Rein, H. and M. Schneider. Die Auswirkung Kunstlicher Mangel durchblutung auf den lokalen Stoffwechsel. Arch. Ges. Physiol. 239: 451–463, 1938.CrossRefGoogle Scholar
  10. 10.
    Ross, J.M., H.M. Fairchild, J.J. Weldy and A.C. Guyton. Autoregulation of blood flow by oxygen lack. Am. J. Physiol. 202: 21–24, 1962.PubMedGoogle Scholar
  11. 11.
    Sinagowitz, E., H. Rahmer, R. Rink, L. Gornandt, M. Kessler. Local oxygen supply in intra-abdominal organs and in skeletal muscle during hemorrhagic shock. Advances in Exptl. Med. and Bio., 37A, ed. by H.I. Bicher and D.F. Bruley, 505–511, O.T.T. 1973.Google Scholar
  12. 12.
    Stainsby, W.N. and A.B. Otis. Blood flow, blood oxygen tension, oxygen uptake and oxygen transport in skeletal muscle. Am. J. Physiol. 206: 858–866, 1964.PubMedGoogle Scholar
  13. 13.
    Van Liew, H.D. Regional heterogeneity of PCo2 and Po2 in skeletal muscle. Advances in Exptl. Med. and Biol., 37A, ed. by HI.I. Bicher and D.F. Bruley, 457–465. O.T.T 1973.Google Scholar
  14. 14.
    Verzar, F. The gaseous metabolism of striated muscle in warmblooded animals. J. Physiol., London 44: 243–258, 1912.Google Scholar
  15. 15.
    Whalen, W.J., D. Buerk and C.A. Thuning. Blood flow-limited oxygen consumption in resting cat skeletal muscle. Am. J. Physiol. 224: 763–768, 1973.PubMedGoogle Scholar
  16. 16.
    Whalen, W.J. and P. Nair. Skeletal muscle Po2: effect of inhaled and topically applied O2 and CO2. Am. J. Physiol. 218: 973–980, 1970.PubMedGoogle Scholar
  17. 17.
    Whalen, W.J., J. Riley, and P. Nair. A microelectrode for measuring intracellular Po2. J. Appl. Physiol. 23: 798–801, 1967.PubMedGoogle Scholar
  18. 18.
    Wright, D.L. and R.R. Sonnenschein. Relations among activity, blood flow, and vascular state in skeletal muscle. Am. J. Physiol. 208: 782–789, 1965.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. J. Whalen
    • 1
  • D. Buerk
    • 1
  • C. Thuning
    • 1
  • B. E. KanoyJr.
    • 2
  • W. N. Duran
    • 2
  1. 1.St. Vincent Charity HospitalClevelandUSA
  2. 2.Dept. of Physiology and PharmacologyDuke University Medical CenterDurhamUSA

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