Mechanisms of Circulation Metabolism Coupling in Skeletal Muscle

  • C. R. Honig
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Post-contraction vasodilation is unaffected by extrinsic denervation (3). It is therefore believed that local metabolites fully account for the phenomenon. Recently, however, neuronal cell bodies have been identified in the walls of arteries and arterioles (8). The experiments to be described indicate that these intrinsic nerves initiate post-contraction vasodilation. A unifying hypothesis is proposed which assigns specific functions to extrinsic sympathetic nerves, intrinsic nerves and metabolites in control of circulation during muscle contraction.


Skeletal Muscle Neuronal Cell Body Gracilis Muscle Minimum Resistance Unify Hypothesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bolme, P. and J. Novotny. Conditional reflex activation of the sympathetic cholinergic vasodilator nerves in the dog. Acta Physiol. Scand. 77: 58, 1969.PubMedCrossRefGoogle Scholar
  2. 2.
    Dobson, J. G. , Jr., R. Rubio, and R. M. Berne. Role of adenine nucleotides, adenosine and inorganic phosphate in the regulation of skeletal muscle blood flow. Circ. Res, 29: 375, 1971.PubMedCrossRefGoogle Scholar
  3. 3.
    Hilton, S. M. Experiments on the post-contraction hyperemia of skeletal muscle. J. Physiol. (Lond.) 120: 230, 1953.Google Scholar
  4. 4.
    Honig, C. R., J. L. Frierson, and R. F. Rakowski. Mechanism of post-occlusion hyperemia. Fed. Proc. 33: 393abs, 1974.Google Scholar
  5. 5.
    Honig, C. R. and J. L. Frierson. Evidence that neurones intrinsic to arterioles initiate post-contraction hyperemia. Am. J. Physiol. Submitted.Google Scholar
  6. 6.
    Mohrman, D. E. and H. V. Sparks. Role of potassium ions in the vascular response to a brief tetanus. Circ. Research 35: 384, 1974.CrossRefGoogle Scholar
  7. 7.
    Myers, H. A. and C. Honig. Influence of initial resistance in magnitude of response to vasomotor stimuli. Am. J. Physiol. 216: 1429, 1969.PubMedGoogle Scholar
  8. 8.
    Myers, H. A., E. A. Schenk, and C. R. Honig. Ganglion cells in arterioles of skeletal muscle: role in sympathetic vasodilation. Am. J. Physiol. Accepted.Google Scholar
  9. 9.
    Scott, J. B., R. M. Daughterty, Jr., J. M. Dabney, and F. J. Haddy. Role of chemical factors in regulation of flow through kidney, hindlimb and heart. Am. J. Physiol. 208: 813, 1965.PubMedGoogle Scholar
  10. 10.
    Skinner, N. S. and W. J. Powell, Jr. Action of oxygen and potassium on vascular resistance of dog skeletal muscle. Am. J. Physiol. 213: 533, 1967.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • C. R. Honig
    • 1
  1. 1.Department of Physiology, School of Medicine and DentistryUniversity of RochesterRochesterUSA

Personalised recommendations