Preliminary Observations of Oxygen Levels in Microcirculation of Tumors in C3H Mice
Fundamental understanding of the oxygen level in microvasculature and tissues of developing tumors may be of great import in elucidation of observed radioresistance and decreased radiation sensitivity of certain tumors in humans. Frequently radiation therapy which at certain doses causes death of cells in vitro fails to kill the cells in vivo, even though the doses are comparable. L. H. Gray, et al, 1953, demonstrated reduced radiation sensitivity of cells which are oxygen deficient. Therefore, this study was undertaken to demonstrate whether changes in microvasculature and microcirculation play a significant role in the oxygen deficiency of various portions of a tumor in vivo.
KeywordsOxygen Level Spontaneous Mammary Tumor Close Circuit Television Platinum Microelectrode Oxygen Delivery Index
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