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Preliminary Observations of Oxygen Levels in Microcirculation of Tumors in C3H Mice

  • H. W. Puffer
  • N. E. Warner
  • L. D. Schaeffer
  • R. W. Wetts
  • M. Bradbury
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

Fundamental understanding of the oxygen level in microvasculature and tissues of developing tumors may be of great import in elucidation of observed radioresistance and decreased radiation sensitivity of certain tumors in humans. Frequently radiation therapy which at certain doses causes death of cells in vitro fails to kill the cells in vivo, even though the doses are comparable. L. H. Gray, et al, 1953, demonstrated reduced radiation sensitivity of cells which are oxygen deficient. Therefore, this study was undertaken to demonstrate whether changes in microvasculature and microcirculation play a significant role in the oxygen deficiency of various portions of a tumor in vivo.

Keywords

Oxygen Level Spontaneous Mammary Tumor Close Circuit Television Platinum Microelectrode Oxygen Delivery Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cater, D.B., Grigson, C.M.B., and Watkinson, D.A. Changes of oxygen tension in tumors induced by vasoconstrictor and vasodilator drugs. Acta Radiologica 58: 401–434 (1962).PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. W. Puffer
    • 1
    • 2
  • N. E. Warner
    • 1
    • 2
  • L. D. Schaeffer
    • 1
    • 2
  • R. W. Wetts
    • 1
    • 2
  • M. Bradbury
    • 1
    • 2
  1. 1.Department of Pathology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Physiology, School of DentistryUniversity of Southern CaliforniaLos AngelesUSA

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