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Control Mechanisms of Oxygen and Glucose Utilization in Tumours

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Oxygen Transport to Tissue — II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 75))

Abstract

Most living cells depend on oxygen and glucose utilization to obtain the chemical energy necessary to maintain their functions and growth. Tumour cells are no exception to this rule though they may differ from other cell types in their mechanisms of control of oxygen and glucose utilization.

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Bibliography

  1. H. Reinhold. Improved microcirculation in irradiated tumours. Europ. J. Cancer, 8, 267, 1972.

    Google Scholar 

  2. M. Gosalvez, R.G. Thurman, B. Chance and H. Reinhold. Regional variation in the oxygenation of mouse mammary tumours in vivo demonstrated by fluorescence of pyridine nucleotide. Brit. J. Radiol., 45, 510, 1972.

    Article  PubMed  CAS  Google Scholar 

  3. O. Warburg. The metabolism of tumours. London, Arnold Constable, 1936.

    Google Scholar 

  4. F. Dickens and H. Weil Malherbe. Metabolism of intestinal mucous membrane. Biochem. J. 35, 7, 1941.

    PubMed  CAS  Google Scholar 

  5. F. Dickens and H. Weil Malherbe. A note on the metabolism of kidney. Biochem. J. 30, 659, 1936.

    PubMed  CAS  Google Scholar 

  6. C.N. Graymore. General aspects of the metabolism of the retina. in The Eye (Dawson H. ed.) vol. I, p. 601, Academic Press, New York.

    Google Scholar 

  7. O. Warburg. On respiratory impairment in cancer cells. Science, 124, 269, 1956.

    PubMed  CAS  Google Scholar 

  8. M.J. Figueras and M. Gosalvez. Inhibition of the growth of Ehrlich ascites tumours with the respiratory inhibitor rotenone. Europ. J. Cancer, 9, 529, 1973.

    CAS  Google Scholar 

  9. M. Gosalvez, M. Blanco, J. Hunter, M. Miko and B. Chance. Effects of anticancer agents on the respiration of isolated mitochondria and tumour cells. Europ. J. Cancer, vol. 10, 567, 1974.

    CAS  Google Scholar 

  10. L. Pasteur. Experiences et vues nouvelles sur la nature des fermentation. C.R. Acad. Sci. 52, 1260, 1861.

    Google Scholar 

  11. H.C. Crabtree. Observations on the carbohydrate metabolism of tumours. Biochemical J. 23, 536, 1929.

    CAS  Google Scholar 

  12. H.A. Krebs. The Pasteur effect and the relations between respiration and fermentation. Essays in biochemistry. Vol. 8, 1–34, Academic Press, London, 1972.

    PubMed  CAS  Google Scholar 

  13. F. Lynen. Uber den aeroben phosphat bedarf den Hefe. Ein zur kenntnis der pasteur’s chen reaction. Justus liebigs Ann. Chem., 546, 120, 1941.

    Article  CAS  Google Scholar 

  14. M. Johnson. The role of aerobic phosphorylation in the Pasteur effect. Science, 94, 2000, 1941.

    Google Scholar 

  15. F. Lynen, G. Hartmann, K.F. Netter and A. Schnegraf. Phosphate turnover and Pasteur effect. In Ciba Foundation Symposium on regulation of cell metabolism (Wolstenholme, G.E.W. and O’Connor, C.M. eds.) pp. 256–273, J.H. Churchill, London.

    Google Scholar 

  16. K.K. Lonberg-Holm. A direct study of intracellular glycolysis in Ehrlich ascites tumours. Biochem. Biophys. Acta, 35, 464, 1959.

    Article  PubMed  CAS  Google Scholar 

  17. T.H. Bucher. Zellulare Kondination Energie Transformierender Stoffwechsel ketten. Ang. Chem., 71, 744, 1959.

    Google Scholar 

  18. T.E. Mansour and J.M. Mansour. Effects of serotonin (5-hydroxy-tryptamine) and adenosine 3,5-phosphate on phosphofructokinase from the liver fluke, Fasciola hepatica. J. Biol. Chem., 237, 629, 1962.

    PubMed  CAS  Google Scholar 

  19. J.V. Passonneau and O.H. Lowry. Phosphofruetokinase and the Pasteur effect. Biochem. Biophys. Res. Commun. 7, 10–15, 1962.

    Article  PubMed  CAS  Google Scholar 

  20. S. Weinhouse, J.B. Shatton, W.E. Criss and H.P. Morris. Molecular forms of enzymes in cancer. Biochimie, 54, 685, 1972.

    Article  PubMed  CAS  Google Scholar 

  21. F.A. Farina, R.C. Adelman, Chai Ho Lo, H.P. Morris and S. Weinhouse. Metabolic regulation and enzyme alterations in the Morris hepatomas. Cancer Research, 28, 1897, 1968.

    PubMed  CAS  Google Scholar 

  22. S. Weinhouse. Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. Cancer Research 32, 2007, 1972.

    Google Scholar 

  23. J.B. Shatton, H.P. Morris and S. Weinhouse. Kinetic, Electrophoretic, and Chromatographic studies on glucose-ATP phosphotransferases in rat liver and hepatomas. Cancer Research 29, 1161, 1969.

    PubMed  CAS  Google Scholar 

  24. C.H. Lo, V.J. Cristofalo, H.P. Morris and S. Weinhouse. Studies on respiration and glycolysis in transplanted hepatic tumors of the rat. Cancer Research 28, 1–10, 1968.

    PubMed  CAS  Google Scholar 

  25. M. Gosalvez, J. Perez-Garcia and S. Weinhouse. Competition for ADP between pyruvate kinase and mitochondrial oxidative phosphorylation as a control mechanism in glycolysis. Eur. J. Biochem. 46, 133, 1974.

    Article  PubMed  CAS  Google Scholar 

  26. M. Gosalvez, L. Lopez-Alarcon, S. Garcia-Suarez, A. Montalvo and S. Weinhouse. Stimulation of respiration of Ehrlich

    Google Scholar 

  27. L. Lopez-Alarcon and M. Gosalvez. A method to measure glycolysis in cell suspensions by means of a sensitive recording pHmeter. Rev. Esp. Fisiol., in press, 1975.

    Google Scholar 

  28. J.E. Feliu, J.J. Diaz-Gil, R. Garcia-Canero and M. Gosalvez. Interconvertible forms of Class A pyruvate kinase from Ehrlich ascites tumour cells. Accepted FEBS Letters, January, 1975.

    Google Scholar 

  29. P.L. Pedersen. Enzymology, ultrastructure, and energetics of mitochondria from three Morris hepatomas of widely different growth rate. GANN Monograph on Cancer Research, 13, 251, 1972.

    Google Scholar 

  30. A.C. Aisenberg. Studies on normal and neoplastic mitochondria I. Respiration. Cancer Research 21, 295, 1961.

    PubMed  CAS  Google Scholar 

  31. M. Gosalvez, L. Lopez-Alarcon and S. Garcia-Suarez. In preparation.

    Google Scholar 

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© 1976 Plenum Press, New York

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Gosalvez, M., Weinhouse, S. (1976). Control Mechanisms of Oxygen and Glucose Utilization in Tumours. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_69

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  • DOI: https://doi.org/10.1007/978-1-4684-3273-2_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3275-6

  • Online ISBN: 978-1-4684-3273-2

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