Computation of Glucose and O2 Concentration Distribution in the Intercapillary Region of Intact Tumor Tissue Considering the Decrease in Substrate Consumption in the Unsaturated Region of Cancer Cell Glycolysis and Respiration

  • M. von Ardenne
  • A. von Ardenne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


With the aid of the diffusion field equations and the numerical values of the equation parameters given in the preceding paper [1] we have calculated the microtopography of glucose and O2 concentration in the intercapillary region of intact tumor tissue, taking into account that substrate consumption decreases in the unsaturated region of cancer cell glycolysis and respiration. The result is shown in Pig. 1 B. The critical supply radii RGk = 0.4 mg% and RO2 = 2.3/1 Torr for maintained proliferation — compared to former computations [2] — increase by a factor of almost 1.8. Pig. 1 A shows the variation in distance R between capillary centre and cancer cells obtained with tumors in their various stages (model DS-Carcino-sarcoma) and with healthy tissue as measured in [2].


Concentration Distribution Substrate Consumption Cell Cycle Synchronization Capillary Centre Unsaturated Region 
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  1. [1]
    A. von Ardenne — M.von Ardenne, Vortrag auf der 2nd Intera.Conf. on Oxygen Transp. to Tissue. Mainz, 12.–14.3.1975.Google Scholar
  2. [2]
    P. Vaupel, Habilitationsschrift der medizinischen Fachbereiche. Universität Mainz, 1973.Google Scholar
  3. [3]
    M. von Ardenne — F. Rieger, Z. Naturforschg. 21b, 472, 1966.Google Scholar
  4. [4]
    M. von Ardenne, 2nd Edition, VEB Verlag Volk und Gesundheit, Berlin, 1970/71.Google Scholar
  5. [5]
    M. von Ardenne, Radiobiol.Radiother. 16,, 1975.Google Scholar
  6. [6]
    M. von Ardenne, Z.Naturforschg. 27b, 1547, 1972.Google Scholar
  7. [7]
    M. von Ardenne, Wiener Klin.Wochenschr. 86,, 1974.Google Scholar
  8. [8]
    M. von Ardenne, Naturwiss. 60, 483, 1973.CrossRefGoogle Scholar
  9. [9]
    M. von Ardenne — P.G. Reitnauer, Z. Naturforschg. 29c 425, 1974.Google Scholar
  10. [10]
    M. von Ardenne — A. von Ardenne, Arzneimittelforschg. 24,, 1974.Google Scholar
  11. [11]
    M. von Ardenne, Z.ärztl.Fortbildg. 68,, 1974.Google Scholar
  12. [12]
    M. von Ardenne — A. von Ardenne, Archiv Geschwulstforschg. 43,, 1974.Google Scholar
  13. [13]
    S. Peel — D.M. Cowen, Brit.J.Cancer 27, 72, 1973.PubMedCrossRefGoogle Scholar
  14. [14]
    M. von Ardenne — P.G. Reitnauer, Arzneimittelforschg. 25,, 1975.Google Scholar
  15. [15]
    M. von Ardenne — W. Krüger, Archiv Geschwulstforschg. 45,, 1975.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. von Ardenne
    • 1
  • A. von Ardenne
    • 1
  1. 1.Forschungsinstitut Manfred von ArdenneDresdenGDR (Germany)

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