Pathophysiological Aspects of Glucose Uptake by the Tumor Tissue under Various Conditions of Oxygen and Glucose Supply

  • P. Vaupel
  • G. Thews
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Earlier examinations of the glucose uptake in neoplastic tissue by isolated DS- Carcinosarcoma implanted into the rat kidney had the results as follows (VAUPEL, 1974):
  1. 1.

    An increase of the tumor mass from 3 to 13 g wet weight caused an exponential decrease of the glucose consumption by the tumor tissue from 44.4 to 6.7/umoles per 100 g/min; very young tumors of 3 – 4 g bad uptake rates from 27.8 to 44.4/umoles/100 g/min.

  2. 2.

    Simultaneous measurements of the mean actual glucose concentrations in the tumor tissue showed that in the very young tumors the concentration still ranged from 1.75 to 2.25/umoles/g wet weight, whereas those in old tumors drop as low as 0 to 0.17/umoles/g.



Glucose Uptake Glucose Consumption Ehrlich Ascites Carcinoma Glucose Uptake Rate Ascites Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. Vaupel
    • 1
  • G. Thews
    • 1
  1. 1.Institute of PhysiologyUniversity of MainzMainzFed.Rep. Germany

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