O2 Supply Conditions in Tumor Tissue in Vivo

  • G. Thews
  • P. Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


During the last few years O2 supply of tumor tissue has very carefully been investigated using GULLINO’ s model of a “tissue isolated” implantation tumor (GULLINO and GRANTHAM, 1961; GÜNTHER et al., 1972; VAUPEL et al., 1971; VAUPEL, 1974). We analysed the O2 supply for a DS-Carcinosarcoma in the rat kidney by two methods:
  1. 1.

    direct measurement of O2 pressures in the tissue by means of gold micro-electrodes,

  2. 2.

    PO2 calculation according to diffusion laws considerring the experimentally determined parameters in the arterial and venous blood.



Tumor Tissue Tumor Weight Implantation Tumor Supply Condition Capillary Length 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • G. Thews
    • 1
  • P. Vaupel
    • 1
  1. 1.Institute of PhysiologyUniversity of MainzMainzFederal Republic of Germany

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