Abstract
During the last few years O2 supply of tumor tissue has very carefully been investigated using GULLINO’ s model of a “tissue isolated” implantation tumor (GULLINO and GRANTHAM, 1961; GÜNTHER et al., 1972; VAUPEL et al., 1971; VAUPEL, 1974). We analysed the O2 supply for a DS-Carcinosarcoma in the rat kidney by two methods:
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1.
direct measurement of O2 pressures in the tissue by means of gold micro-electrodes,
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2.
PO2 calculation according to diffusion laws considerring the experimentally determined parameters in the arterial and venous blood.
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References
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GÜNTHER, H., VAUPEL, P., METZGER, H., THEWS G.: Steady state distribution of PO2 values in tumor tissue (DS- Carcinosarcoma). I. Measurements in vivo using gold microelectrodes. Z. Krebsforsch. 77, 26 – 39 (1972)
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THEWS, G.: Über die mathematische Behandlung physiologischer Diffusionsprozesse in zylinderförmigen Objekten, Acta biotheor. (Leiden) 10, 105 – 138 (1953)
VAUPEL, P.: Atemgaswechsel und Glucosestoffwechsel von Implantationstumoren (DS- Carcinosarkom) in vivo. Experimentelle Untersuchungen und theoretische Analysen zur Frage der kritischen Sauerstoff- und Glucoseversorgung im Tumorgewebe. In: Funktionsanalyse biologischer Systeme (Vol. 1). Ed.: G. Thews (Steiner, Wiesbaden 1974)
VAUPEL, P., GÜNTHER, H., GROTE, J., AUMÜLLER, G.: Respiratory gas exchange and glucose metabolism of tumors (DS- Carcinosarcoma) in vivo. Z. ges. exp. Med. 156, 283 – 294 (1971)
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© 1976 Plenum Press, New York
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Thews, G., Vaupel, P. (1976). O2 Supply Conditions in Tumor Tissue in Vivo. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_63
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DOI: https://doi.org/10.1007/978-1-4684-3273-2_63
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