In Vivo Utilization of Oxygen and Glucose by Neoplastic Tissue

  • Pietro M. Gullino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


The biological role of oxygen utilization and glucose consumption in the survival and growth of tumors was first emphasized by Warburg (1,2). For many years the experimental approach in this field relied upon manometric techniques, tissue slices, and homogenates. The overriding preoccupation of investigators was the aerobic glycolysis as a lesion pathognomonic of neoplastic transformation. Only in 1961 (3) was a tumor preparation developed which permitted measurements of oxygen and glucose consumption by solid tumors in vivo following standard physiological procedures (4–9).


Glucose Consumption Lactate Production NEOPLASTIC Tissue Oxygen Utilization Free Glucose 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Pietro M. Gullino
    • 1
  1. 1.Laboratory of Pathophysiology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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