A Factor in Longitudinal Tissue Gradients: Red Cell Carriage

  • Carl A. Goresky
  • Glen G. Bach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


The uptake of oxygen and other substrates from a microcirculatory channel will result in a falling gradient in concentration, from input to output, both within the vascular lumen and within the adjacent tissue. When the materials being extracted are being carried both within the plasma and the red cell, and when the exchange between the red cell and plasma is not instantaneous, a part of the material will be temporarily sequestered within the red cell and will be carried somewhat further along the channel than otherwise would have occurred, before being released to the plasma phase, for removal. The phenomenon of red cell carriage (the trapping and translocation of material within the red cells) will occur, in the case of oxygen, because of both the relatively slow rate of release from oxyhemoglobin and a limiting permeability at the red cell membrane.


Tritiated Water Label Water Montreal General Hospital Hepatic Venous Blood Outflow Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Goresky, C.A. A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 204: 626–640, 1963.PubMedGoogle Scholar
  2. 2.
    Hamilton, W.F., J.W. Moore, J.M. Kinsman, and R.G. Spurling. Simultaneous determination of the pulmonary and systemic circulation times in man and of a figure related to the cardiac output. Am. J. Physiol. 84: 338–344, 1928.Google Scholar
  3. 3.
    Goresky, C.A., G.G. Bach, and B.E. Nadeau. Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Circ. Res. 36: 328–351, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Paganelli, C.V., and A.K. Solomon. The rate of exchange of tritiated water across the human red cell membrane. J, Gen, Physiol. 41: 259–277, 1957.CrossRefGoogle Scholar
  5. 5.
    Jacobs, M.H., H.N. Glassman, and A.K. Parpart. Hemolysis and zoological relationship, Comparative studies with four penetrating non-electrolytes, J. Expt. Zool. 113: 277–300, 1950.CrossRefGoogle Scholar
  6. 6.
    Goresky, C.A., G.G. Bach, and B.E. Nadeau. On the uptake of materials by the intact liver: the transport and net removal of galactose. J. Clin. Invest. 52: 991–1008, 1973.PubMedCrossRefGoogle Scholar
  7. 7.
    Roughton, F.J.W. Diffusion and simultaneous reaction velocity in hemoglobin solutions and red cell suspensions. In Progress in Biophysics. Volume 9, pp 55–104, 1959.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Carl A. Goresky
    • 1
    • 2
  • Glen G. Bach
    • 1
    • 2
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada
  2. 2.Departments of Medicine and Mechanical EngineeringMcGill UniversityMontrealCanada

Personalised recommendations