Effect of Ionizing Radiation on Liver Microcirculation and Oxygenation
Ionizing radiation causes destruction of mammalian tissue by two mechanisms (11): 1) inhibition of the proliferative capacity of rapidly dividing cells, and 2) irreversible damage to elements of the microcirculatory system. Organs such as liver, kidney, and brain, not characterized by rapidly proliferating cells, exhibit a relatively pronounced radiosensitivity in spite of a very slow rate of cellular turnover. The radiosensitivity of the microcirculation could provide the reason for the radiosensitivity of the entire organ or tissue.
KeywordsPlatelet Aggregation Platelet Adhesiveness Microcirculation Disturbance Microcirculatory System Photoelectric Method
Unable to display preview. Download preview PDF.
- 2.Bicher, H.I. Anti-adhesive drugs in thrombosis. Throm. et DiathHaem., Suppl. 42:197, 1970.Google Scholar
- 7.Bicher, H.I., Marvin, P., Hunt, D.H., and Bruley, D.F. Autonomic and pharmacologic control of oxygen autoregulation mechanisms in brain tissue. ISOTT Symposium, Mainz, Germany, 1975. (To be published by Plenum Press, N.Y.)Google Scholar
- 8.Born, G.V. Quantitative investigations into aggregation of blood platelets. J. Physiol., 162:67p, 1962.Google Scholar
- 9.Ingold, J., Reed, G. and Kaplan, M.D. Am. J. Roentgenology, 93:200, 1965.Google Scholar